Ca2+ homeostasis and regulation of ER Ca2+ in mammalian oocytes/eggs

Takuya Wakai, Rafael A. Fissore

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


The activation of the developmental program in mammalian eggs relies on the initiation at the time of fertilization of repeated rises in the intracellular concentration of free calcium ([Ca2+]i), also known as [Ca2+]i oscillations. The ability to mount the full complement of oscillations is only achieved at the end of oocyte maturation, at the metaphase stage of meiosis II (MII). Over the last decades research has focused on addressing the mechanisms by which the sperm initiates the oscillations and identification of the channels that mediate intracellular Ca2+ release. This review will describe the up-to-date knowledge of other aspects of Ca2+ homeostasis in mouse oocytes, such as the mechanisms that transport Ca2+ out of the cytosol into the endoplasmic reticulum (ER), the Ca2+ store of the oocyte/egg, into other organelles and also those that extrude Ca2+. Evidence pointing to channels in the plasma membrane that mediate Ca2+ entry from the extracellular milieu, which is required for the persistence of the oscillations, is also discussed, along with the modifications that these mechanisms undergo during maturation. Lastly, we highlight areas where additional research is needed to obtain a better understating of the molecules and mechanisms that regulate Ca2+ homeostasis in this unique Ca2+ signaling system.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalCell Calcium
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes


  • Eggs
  • Mouse
  • Oocytes
  • SOCE

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Ca2+ homeostasis and regulation of ER Ca2+ in mammalian oocytes/eggs'. Together they form a unique fingerprint.

Cite this