Ca2+ signaling during mammalian fertilization: Requirements, players, and adaptations

Takuya Wakai, Veerle Vanderheyden, Rafael A. Fissore

Research output: Contribution to journalReview articlepeer-review

52 Citations (Scopus)


Changes in the intracellular concentration of calcium ([Ca2+]i) represent a vital signaling mechanism enabling communication among cells and between cells and the environment. The initiation of embryo development depends on a [Ca2+]i increase(s) in the egg, which is generally induced during fertilization. The [Ca2+]i increase signals egg activation, which is the first stage in embryo development, and that consist of biochemical and structural changes that transform eggs into zygotes. The spatiotemporal patterns of [Ca2+]i at fertilization show variability, most likely reflecting adaptations to fertilizing conditions and to the duration of embryonic cell cycles. In mammals, the focus of this review, the fertilization [Ca2+]i signal displays unique properties in that it is initiated after gamete fusion by release of a sperm-derived factor and by periodic and extended [Ca2+]i responses. Here, we will discuss the events of egg activation regulated by increases in [Ca2+]i, the possible downstream targets that effect these egg activation events, and the property and identity of molecules both in sperm and eggs that underpin the initiation and persistence of the [Ca2+]i responses in these species.

Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalCold Spring Harbor Perspectives in Biology
Issue number4
Publication statusPublished - Apr 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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