Caveolin-1 as tumor suppressor gene in breast cancer

Masato Hino, Hiroyoshi Doihara, Kazuyasu Kobayashi, Motoi Aoe, Nobuyoshi Shimizu

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Purpose. Many articles have reported the caveolin-1 gene to be downregulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors, but in bladder tumors the caveolin-1 gene was expressed and related to the pathological grade. We investigated the function of caveolin-1 protein in breast tumors. Methods. We introduced the caveolin-1 gene into a MCF-7 human breast cancer cell line, and examined its cell growth, cell viability, and anchorage-independent growth. Results. The caveolin-1 transfectants showed less proliferation than the vector control transfectants on the fourth day regarding the cell growth rate. In addition, the cell viability of the caveolin-1 transfectants was about 55 % of the vector control. A soft agar assay of the caveolin-1 transfectants showed less growth with a lower number of colonies. Conclusion. In MCF-7 cells, the caveolin-1 gene may influence the tumor suppressor efficacy.

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalSurgery today
Issue number7
Publication statusPublished - 2003


  • Caveolin-1
  • Cell growth
  • MCF-7

ASJC Scopus subject areas

  • Surgery


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