CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer

Keizo Tokumo; Junichi Kodama; Noriko Seki; Yasunari Miyagi; Mitsuo Yoshinouchi; Takafumi Kudo

doi:10.1016/S0304-3835(97)00517-X

CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer

Keizo Tokumo, Junichi Kodama, Noriko Seki, Yasunari Miyagi, Mitsuo Yoshinouchi, Takafumi Kudo

University Hospital

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We examined the presence of mRNA for CD44v6 and assessed the association with clinicopathological features in 42 patients with endometrial cancer by RT-PCR and subsequent Southern blot hybridization with oligonucleotide probe specific for v6. The standard form of CD44 was expressed in all specimens and 20 out of 42 endometrial cancers expressed an isoform containing exon v6 in combination with other variant exons. However, there was no correlation between the expression of CD44v6 and any clinicopathological factors. These findings suggested that the expression of CD44v6 is not implicated in the progression and metastasis of endometrial cancer.

Original language	English
Pages (from-to)	221-225
Number of pages	5
Journal	Cancer Letters
Volume	125
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(97)00517-X
Publication status	Published - Mar 13 1998

Keywords

CD44v6
Endometrial cancer
Metastasis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(97)00517-X

Cite this

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title = "CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer",

abstract = "We examined the presence of mRNA for CD44v6 and assessed the association with clinicopathological features in 42 patients with endometrial cancer by RT-PCR and subsequent Southern blot hybridization with oligonucleotide probe specific for v6. The standard form of CD44 was expressed in all specimens and 20 out of 42 endometrial cancers expressed an isoform containing exon v6 in combination with other variant exons. However, there was no correlation between the expression of CD44v6 and any clinicopathological factors. These findings suggested that the expression of CD44v6 is not implicated in the progression and metastasis of endometrial cancer.",

keywords = "CD44v6, Endometrial cancer, Metastasis",

author = "Keizo Tokumo and Junichi Kodama and Noriko Seki and Yasunari Miyagi and Mitsuo Yoshinouchi and Takafumi Kudo",

note = "Funding Information: We thank Drs A. Disso and C. Sorenson for assistance in the preparation of the manuscript. This work was supported in part by grants-in-aid for Scientific Research (09771277 and 09671684) from the Ministry of Education, Sport, Science and Culture, Japan. ",

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doi = "10.1016/S0304-3835(97)00517-X",

language = "English",

volume = "125",

pages = "221--225",

journal = "Cancer Letters",

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TY - JOUR

T1 - CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer

AU - Tokumo, Keizo

AU - Kodama, Junichi

AU - Seki, Noriko

AU - Miyagi, Yasunari

AU - Yoshinouchi, Mitsuo

AU - Kudo, Takafumi

N1 - Funding Information: We thank Drs A. Disso and C. Sorenson for assistance in the preparation of the manuscript. This work was supported in part by grants-in-aid for Scientific Research (09771277 and 09671684) from the Ministry of Education, Sport, Science and Culture, Japan.

PY - 1998/3/13

Y1 - 1998/3/13

N2 - We examined the presence of mRNA for CD44v6 and assessed the association with clinicopathological features in 42 patients with endometrial cancer by RT-PCR and subsequent Southern blot hybridization with oligonucleotide probe specific for v6. The standard form of CD44 was expressed in all specimens and 20 out of 42 endometrial cancers expressed an isoform containing exon v6 in combination with other variant exons. However, there was no correlation between the expression of CD44v6 and any clinicopathological factors. These findings suggested that the expression of CD44v6 is not implicated in the progression and metastasis of endometrial cancer.

AB - We examined the presence of mRNA for CD44v6 and assessed the association with clinicopathological features in 42 patients with endometrial cancer by RT-PCR and subsequent Southern blot hybridization with oligonucleotide probe specific for v6. The standard form of CD44 was expressed in all specimens and 20 out of 42 endometrial cancers expressed an isoform containing exon v6 in combination with other variant exons. However, there was no correlation between the expression of CD44v6 and any clinicopathological factors. These findings suggested that the expression of CD44v6 is not implicated in the progression and metastasis of endometrial cancer.

KW - CD44v6

KW - Endometrial cancer

KW - Metastasis

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DO - 10.1016/S0304-3835(97)00517-X

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AN - SCOPUS:0032513275

SN - 0304-3835

VL - 125

SP - 221

EP - 225

JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

CD44 exon v6 is not implicated in the progression and metastasis of endometrial cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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