Ceftriaxone-induced neurotoxicity in a patient after pancreas-kidney transplantation

Hideharu Hagiya; Koji Miyawaki; Norihisa Yamamoto; Hisao Yoshida; Akihiro Kitagawa; Tadafumi Asaoka; Hidetoshi Eguchi; Yukihiro Akeda; Kazunori Tomono

doi:10.2169/internalmedicine.8774-16

Ceftriaxone-induced neurotoxicity in a patient after pancreas-kidney transplantation

Hideharu Hagiya, Koji Miyawaki, Norihisa Yamamoto, Hisao Yoshida, Akihiro Kitagawa, Tadafumi Asaoka, Hidetoshi Eguchi, Yukihiro Akeda, Kazunori Tomono

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and a broad antimicrobial spectrum. We herein report a case of ceftriaxone-induced neurotoxicity in a 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus and sporadic phonation. The symptoms clearly disappeared shortly after withdrawal of the drug. Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways. Physicians should note that antibiotic-associated encephalopathy may develop in patients administered ceftriaxone, especially in those complicated with renal dysfunction.

Original language	English
Pages (from-to)	3103-3107
Number of pages	5
Journal	Internal Medicine
Volume	56
Issue number	22
DOIs	https://doi.org/10.2169/internalmedicine.8774-16
Publication status	Published - 2017
Externally published	Yes

Keywords

Antibiotic-associated encephalopathy
Ceftriaxone
Chronic kidney disease
Hemodialysis
Nonconvulsive status epilepticus
Transplantation

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.8774-16

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title = "Ceftriaxone-induced neurotoxicity in a patient after pancreas-kidney transplantation",

abstract = "Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and a broad antimicrobial spectrum. We herein report a case of ceftriaxone-induced neurotoxicity in a 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus and sporadic phonation. The symptoms clearly disappeared shortly after withdrawal of the drug. Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways. Physicians should note that antibiotic-associated encephalopathy may develop in patients administered ceftriaxone, especially in those complicated with renal dysfunction.",

keywords = "Antibiotic-associated encephalopathy, Ceftriaxone, Chronic kidney disease, Hemodialysis, Nonconvulsive status epilepticus, Transplantation",

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T1 - Ceftriaxone-induced neurotoxicity in a patient after pancreas-kidney transplantation

AU - Hagiya, Hideharu

AU - Miyawaki, Koji

AU - Yamamoto, Norihisa

AU - Yoshida, Hisao

AU - Kitagawa, Akihiro

AU - Asaoka, Tadafumi

AU - Eguchi, Hidetoshi

AU - Akeda, Yukihiro

AU - Tomono, Kazunori

PY - 2017

Y1 - 2017

N2 - Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and a broad antimicrobial spectrum. We herein report a case of ceftriaxone-induced neurotoxicity in a 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus and sporadic phonation. The symptoms clearly disappeared shortly after withdrawal of the drug. Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways. Physicians should note that antibiotic-associated encephalopathy may develop in patients administered ceftriaxone, especially in those complicated with renal dysfunction.

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KW - Antibiotic-associated encephalopathy

KW - Ceftriaxone

KW - Chronic kidney disease

KW - Hemodialysis

KW - Nonconvulsive status epilepticus

KW - Transplantation

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Ceftriaxone-induced neurotoxicity in a patient after pancreas-kidney transplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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