Central administration of interleukin-1β reduces natural killer cell activity in non-pregnant rats, but not in pregnant rats

Hiroyuki Nakamura; Toshio Seto; Kotaro Hatta; Ichiyo Matsuzaki; Hirofumi Nagase; Masami Yoshida; Keiki Ogino

doi:10.1016/S0306-4530(98)00037-7

Central administration of interleukin-1β reduces natural killer cell activity in non-pregnant rats, but not in pregnant rats

Hiroyuki Nakamura, Toshio Seto, Kotaro Hatta, Ichiyo Matsuzaki, Hirofumi Nagase, Masami Yoshida, Keiki Ogino

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

To examine responses of natural killer cell activity (NKCA) to interleukin-1β (IL-1β)) during pregnancy, we determined splenic NKCA as well as blood and brain indicators in virgin and pregnant rats (14 or 21 days gestation) with intracerebroventricular (icv) administration of IL-1β. NKCA was reduced and blood β-endorphin (β EP) was increased with the progress of pregnancy. Icv administration of IL-1β reduced NKCA and corticotropin- releasing hormone (CRH) in the median eminence (ME), and increased βEP in virgin rats, but did not change any parameters in pregnant rats with 21 days gestation. These data suggest that the immunosuppressive effect of central administration of IL-1β is blocked by pregnancy. CRH in the ME and opioid system seem to be involved in the inhibitory effect of pregnancy on IL-1β- induced immunosuppression.

Original language	English
Pages (from-to)	651-659
Number of pages	9
Journal	Psychoneuroendocrinology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/S0306-4530(98)00037-7
Publication status	Published - Aug 1998

Keywords

Corticotropin releasing hormone (CRH)
Interleukin- 1β
Natural killer cell activity
Pregnancy
β-endorphin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0306-4530(98)00037-7

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title = "Central administration of interleukin-1β reduces natural killer cell activity in non-pregnant rats, but not in pregnant rats",

abstract = "To examine responses of natural killer cell activity (NKCA) to interleukin-1β (IL-1β)) during pregnancy, we determined splenic NKCA as well as blood and brain indicators in virgin and pregnant rats (14 or 21 days gestation) with intracerebroventricular (icv) administration of IL-1β. NKCA was reduced and blood β-endorphin (β EP) was increased with the progress of pregnancy. Icv administration of IL-1β reduced NKCA and corticotropin- releasing hormone (CRH) in the median eminence (ME), and increased βEP in virgin rats, but did not change any parameters in pregnant rats with 21 days gestation. These data suggest that the immunosuppressive effect of central administration of IL-1β is blocked by pregnancy. CRH in the ME and opioid system seem to be involved in the inhibitory effect of pregnancy on IL-1β- induced immunosuppression.",

keywords = "Corticotropin releasing hormone (CRH), Interleukin- 1β, Natural killer cell activity, Pregnancy, β-endorphin",

author = "Hiroyuki Nakamura and Toshio Seto and Kotaro Hatta and Ichiyo Matsuzaki and Hirofumi Nagase and Masami Yoshida and Keiki Ogino",

note = "Funding Information: This work was supported in part by Grant-in Aid for Scientific Research (C; No. 07670431, C; No. 09670382) from Ministry of Education, Sports, Science and Culture of Japan for 1995–1998. We are indebted to the President of Kanazawa University, Dr Akira Okada for his kind support and interest in this work.",

year = "1998",

month = aug,

doi = "10.1016/S0306-4530(98)00037-7",

language = "English",

volume = "23",

pages = "651--659",

journal = "Psychoneuroendocrinology",

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T1 - Central administration of interleukin-1β reduces natural killer cell activity in non-pregnant rats, but not in pregnant rats

AU - Nakamura, Hiroyuki

AU - Seto, Toshio

AU - Hatta, Kotaro

AU - Matsuzaki, Ichiyo

AU - Nagase, Hirofumi

AU - Yoshida, Masami

AU - Ogino, Keiki

N1 - Funding Information: This work was supported in part by Grant-in Aid for Scientific Research (C; No. 07670431, C; No. 09670382) from Ministry of Education, Sports, Science and Culture of Japan for 1995–1998. We are indebted to the President of Kanazawa University, Dr Akira Okada for his kind support and interest in this work.

PY - 1998/8

Y1 - 1998/8

N2 - To examine responses of natural killer cell activity (NKCA) to interleukin-1β (IL-1β)) during pregnancy, we determined splenic NKCA as well as blood and brain indicators in virgin and pregnant rats (14 or 21 days gestation) with intracerebroventricular (icv) administration of IL-1β. NKCA was reduced and blood β-endorphin (β EP) was increased with the progress of pregnancy. Icv administration of IL-1β reduced NKCA and corticotropin- releasing hormone (CRH) in the median eminence (ME), and increased βEP in virgin rats, but did not change any parameters in pregnant rats with 21 days gestation. These data suggest that the immunosuppressive effect of central administration of IL-1β is blocked by pregnancy. CRH in the ME and opioid system seem to be involved in the inhibitory effect of pregnancy on IL-1β- induced immunosuppression.

AB - To examine responses of natural killer cell activity (NKCA) to interleukin-1β (IL-1β)) during pregnancy, we determined splenic NKCA as well as blood and brain indicators in virgin and pregnant rats (14 or 21 days gestation) with intracerebroventricular (icv) administration of IL-1β. NKCA was reduced and blood β-endorphin (β EP) was increased with the progress of pregnancy. Icv administration of IL-1β reduced NKCA and corticotropin- releasing hormone (CRH) in the median eminence (ME), and increased βEP in virgin rats, but did not change any parameters in pregnant rats with 21 days gestation. These data suggest that the immunosuppressive effect of central administration of IL-1β is blocked by pregnancy. CRH in the ME and opioid system seem to be involved in the inhibitory effect of pregnancy on IL-1β- induced immunosuppression.

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KW - Natural killer cell activity

KW - Pregnancy

KW - β-endorphin

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Central administration of interleukin-1β reduces natural killer cell activity in non-pregnant rats, but not in pregnant rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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