Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats

U. Funada; M. Wada; T. Kawata; K. Mori; H. Tamai; T. Kawanishi; A. Kunou; N. Tanaka; T. Tadokoro; A. Maekawa

doi:10.1024/0300-9831.70.4.167

Changes in CD4⁺CD8^-/CD4^-CD8⁺ ratio and humoral immune functions in vitamin B₁₂-deficient rats

U. Funada, M. Wada, T. Kawata, K. Mori, H. Tamai, T. Kawanishi, A. Kunou, N. Tanaka, T. Tadokoro, A. Maekawa

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

To clarify the role of vitamin B₁₂ in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B₁₂-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4⁺CD8^-/CD4^-CD8⁺ ratio in splenocytes was significantly higher in vitamin B₁₂-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4⁺CD8^-/CD4^-CD8⁺ ratio by vitamin B₁₂-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B₁₂-deficient group than in the control group. These findings suggest that vitamin B₁₂ plays a role in maintaining the immune function in rats.

Original language	English
Pages (from-to)	167-171
Number of pages	5
Journal	International Journal for Vitamin and Nutrition Research
Volume	70
Issue number	4
DOIs	https://doi.org/10.1024/0300-9831.70.4.167
Publication status	Published - Jan 1 2000
Externally published	Yes

Keywords

CD4
CD8
Serum C3
Serum IgG
Serum IgM
Vitamin B-deficiency

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1024/0300-9831.70.4.167

Cite this

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title = "Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats",

abstract = "To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.",

keywords = "CD4, CD8, Serum C3, Serum IgG, Serum IgM, Vitamin B-deficiency",

author = "U. Funada and M. Wada and T. Kawata and K. Mori and H. Tamai and T. Kawanishi and A. Kunou and N. Tanaka and T. Tadokoro and A. Maekawa",

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language = "English",

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AU - Funada, U.

AU - Wada, M.

AU - Kawata, T.

AU - Mori, K.

AU - Tamai, H.

AU - Kawanishi, T.

AU - Kunou, A.

AU - Tanaka, N.

AU - Tadokoro, T.

AU - Maekawa, A.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.

AB - To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.

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