TY - JOUR
T1 - Changes in glomerular extracellular matrices components in diabetic nephropathy
AU - Ikeda, Shuji
AU - Makino, Hirofumi
AU - Haramoto, Toshinori
AU - Shikata, Kenichi
AU - Kumagai, Isao
AU - Ota, Zensuke
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Scientific Research to Dr. Hirofumi Makino (C-01570644) from the Ministry of Education, Science and Culture.
PY - 1991
Y1 - 1991
N2 - The changes in glomerular extracellular matrices components in diabetic nephropathy were investigated. Indirect immunofluorescence staining, using polyclonal antibodies to heparan sulfate proteoglycan (HS-PG), laminin, type IV collagen, and fibronectin was carried out on renal specimens obtained by needle biopsy. Immunofluorescence intensity and distribution were observed. HS-PG and laminin decreased in the capillary walls; on the other hand, type IV collagen and fibronectin tended to increase in the mesangial area. HS-PG and laminin decreased in inverse proportion to sclerosis grades and proteinuria. These changes seemed to play an important role in progression of diabetic glomerulosclerosis.
AB - The changes in glomerular extracellular matrices components in diabetic nephropathy were investigated. Indirect immunofluorescence staining, using polyclonal antibodies to heparan sulfate proteoglycan (HS-PG), laminin, type IV collagen, and fibronectin was carried out on renal specimens obtained by needle biopsy. Immunofluorescence intensity and distribution were observed. HS-PG and laminin decreased in the capillary walls; on the other hand, type IV collagen and fibronectin tended to increase in the mesangial area. HS-PG and laminin decreased in inverse proportion to sclerosis grades and proteinuria. These changes seemed to play an important role in progression of diabetic glomerulosclerosis.
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U2 - 10.1016/0891-6632(91)90068-Z
DO - 10.1016/0891-6632(91)90068-Z
M3 - Article
C2 - 1770041
AN - SCOPUS:0026135401
SN - 1056-8727
VL - 5
SP - 186
EP - 188
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 2-3
ER -
