Characteristic Mean Kurtosis Values in Simple Diffusion Kurtosis Imaging of Dentigerous Cysts

Yuka Fukumura; Masahiro Kuroda; Suzuka Yoshida; Yoshihide Nakamura; Yuki Nakamitsu; Wlla E. Al-Hammad; Kazuhiro Kuroda; Ryo Kamizaki; Yudai Shimizu; Yoshinori Tanabe; Kohei Sugimoto; Masataka Oita; Irfan Sugianto; Majd Barham; Nouha Tekiki; Nurul N. Kamaruddin; Yoshinobu Yanagi; Junichi Asaumi

doi:10.3390/diagnostics13243619

Characteristic Mean Kurtosis Values in Simple Diffusion Kurtosis Imaging of Dentigerous Cysts

Yuka Fukumura, Masahiro Kuroda, Suzuka Yoshida, Yoshihide Nakamura, Yuki Nakamitsu, Wlla E. Al-Hammad, Kazuhiro Kuroda, Ryo Kamizaki, Yudai Shimizu, Yoshinori Tanabe, Kohei Sugimoto, Masataka Oita, Irfan Sugianto, Majd Barham, Nouha Tekiki, Nurul N. Kamaruddin, Yoshinobu Yanagi, Junichi Asaumi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We evaluated the usefulness of simple diffusion kurtosis (SD) imaging, which was developed to generate diffusion kurtosis images simultaneously with an apparent diffusion coefficient (ADC) map for 27 cystic disease lesions in the head and neck region. The mean kurtosis (MK) and ADC values were calculated for the cystic space. The MK values were dentigerous cyst (DC): 0.74, odontogenic keratocyst (OKC): 0.86, ranula (R): 0.13, and mucous cyst (M): 0, and the ADC values were DC: 1364 × 10⁻⁶ mm²/s, OKC: 925 × 10⁻⁶ mm²/s, R: 2718 × 10⁻⁶ mm²/s, and M: 2686 × 10⁻⁶ mm²/s. The MK values of DC and OKC were significantly higher than those of R and M, whereas their ADC values were significantly lower. One reason for the characteristic signal values in diffusion-weighted images of DC may be related to content components such as fibrous tissue and exudate cells. When imaging cystic disease in the head and neck region using SD imaging, the maximum b-value setting at the time of imaging should be limited to approximately 1200 s/mm² for accurate MK value calculation. This study is the first to show that the MK values of DC are characteristically higher than those of other cysts.

Original language	English
Article number	3619
Journal	Diagnostics
Volume	13
Issue number	24
DOIs	https://doi.org/10.3390/diagnostics13243619
Publication status	Published - Dec 2023

Keywords

apparent diffusion coefficient value
dentigerous cyst
diffusion kurtosis imaging
head and neck
magnetic resonance imaging
mean kurtosis
simple diffusion kurtosis imaging

ASJC Scopus subject areas

Clinical Biochemistry

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10.3390/diagnostics13243619

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Fukumura, Y., Kuroda, M., Yoshida, S., Nakamura, Y., Nakamitsu, Y., Al-Hammad, W. E., Kuroda, K., Kamizaki, R., Shimizu, Y., Tanabe, Y., Sugimoto, K., Oita, M., Sugianto, I., Barham, M., Tekiki, N., Kamaruddin, N. N., Yanagi, Y., & Asaumi, J. (2023). Characteristic Mean Kurtosis Values in Simple Diffusion Kurtosis Imaging of Dentigerous Cysts. Diagnostics, 13(24), Article 3619. https://doi.org/10.3390/diagnostics13243619

Fukumura, Y, Kuroda, M, Yoshida, S, Nakamura, Y, Nakamitsu, Y, Al-Hammad, WE, Kuroda, K, Kamizaki, R, Shimizu, Y, Tanabe, Y, Sugimoto, K, Oita, M, Sugianto, I, Barham, M, Tekiki, N, Kamaruddin, NN, Yanagi, Y & Asaumi, J 2023, 'Characteristic Mean Kurtosis Values in Simple Diffusion Kurtosis Imaging of Dentigerous Cysts', Diagnostics, vol. 13, no. 24, 3619. https://doi.org/10.3390/diagnostics13243619

@article{4024b24f17824850b9aa303784aad126,

title = "Characteristic Mean Kurtosis Values in Simple Diffusion Kurtosis Imaging of Dentigerous Cysts",

abstract = "We evaluated the usefulness of simple diffusion kurtosis (SD) imaging, which was developed to generate diffusion kurtosis images simultaneously with an apparent diffusion coefficient (ADC) map for 27 cystic disease lesions in the head and neck region. The mean kurtosis (MK) and ADC values were calculated for the cystic space. The MK values were dentigerous cyst (DC): 0.74, odontogenic keratocyst (OKC): 0.86, ranula (R): 0.13, and mucous cyst (M): 0, and the ADC values were DC: 1364 × 10−6 mm2/s, OKC: 925 × 10−6 mm2/s, R: 2718 × 10−6 mm2/s, and M: 2686 × 10−6 mm2/s. The MK values of DC and OKC were significantly higher than those of R and M, whereas their ADC values were significantly lower. One reason for the characteristic signal values in diffusion-weighted images of DC may be related to content components such as fibrous tissue and exudate cells. When imaging cystic disease in the head and neck region using SD imaging, the maximum b-value setting at the time of imaging should be limited to approximately 1200 s/mm2 for accurate MK value calculation. This study is the first to show that the MK values of DC are characteristically higher than those of other cysts.",

keywords = "apparent diffusion coefficient value, dentigerous cyst, diffusion kurtosis imaging, head and neck, magnetic resonance imaging, mean kurtosis, simple diffusion kurtosis imaging",

author = "Yuka Fukumura and Masahiro Kuroda and Suzuka Yoshida and Yoshihide Nakamura and Yuki Nakamitsu and Al-Hammad, {Wlla E.} and Kazuhiro Kuroda and Ryo Kamizaki and Yudai Shimizu and Yoshinori Tanabe and Kohei Sugimoto and Masataka Oita and Irfan Sugianto and Majd Barham and Nouha Tekiki and Kamaruddin, {Nurul N.} and Yoshinobu Yanagi and Junichi Asaumi",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = dec,

doi = "10.3390/diagnostics13243619",

language = "English",

volume = "13",

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T1 - Characteristic Mean Kurtosis Values in Simple Diffusion Kurtosis Imaging of Dentigerous Cysts

AU - Fukumura, Yuka

AU - Kuroda, Masahiro

AU - Yoshida, Suzuka

AU - Nakamura, Yoshihide

AU - Nakamitsu, Yuki

AU - Al-Hammad, Wlla E.

AU - Kuroda, Kazuhiro

AU - Kamizaki, Ryo

AU - Shimizu, Yudai

AU - Tanabe, Yoshinori

AU - Sugimoto, Kohei

AU - Oita, Masataka

AU - Sugianto, Irfan

AU - Barham, Majd

AU - Tekiki, Nouha

AU - Kamaruddin, Nurul N.

AU - Yanagi, Yoshinobu

AU - Asaumi, Junichi

PY - 2023/12

Y1 - 2023/12

N2 - We evaluated the usefulness of simple diffusion kurtosis (SD) imaging, which was developed to generate diffusion kurtosis images simultaneously with an apparent diffusion coefficient (ADC) map for 27 cystic disease lesions in the head and neck region. The mean kurtosis (MK) and ADC values were calculated for the cystic space. The MK values were dentigerous cyst (DC): 0.74, odontogenic keratocyst (OKC): 0.86, ranula (R): 0.13, and mucous cyst (M): 0, and the ADC values were DC: 1364 × 10−6 mm2/s, OKC: 925 × 10−6 mm2/s, R: 2718 × 10−6 mm2/s, and M: 2686 × 10−6 mm2/s. The MK values of DC and OKC were significantly higher than those of R and M, whereas their ADC values were significantly lower. One reason for the characteristic signal values in diffusion-weighted images of DC may be related to content components such as fibrous tissue and exudate cells. When imaging cystic disease in the head and neck region using SD imaging, the maximum b-value setting at the time of imaging should be limited to approximately 1200 s/mm2 for accurate MK value calculation. This study is the first to show that the MK values of DC are characteristically higher than those of other cysts.

AB - We evaluated the usefulness of simple diffusion kurtosis (SD) imaging, which was developed to generate diffusion kurtosis images simultaneously with an apparent diffusion coefficient (ADC) map for 27 cystic disease lesions in the head and neck region. The mean kurtosis (MK) and ADC values were calculated for the cystic space. The MK values were dentigerous cyst (DC): 0.74, odontogenic keratocyst (OKC): 0.86, ranula (R): 0.13, and mucous cyst (M): 0, and the ADC values were DC: 1364 × 10−6 mm2/s, OKC: 925 × 10−6 mm2/s, R: 2718 × 10−6 mm2/s, and M: 2686 × 10−6 mm2/s. The MK values of DC and OKC were significantly higher than those of R and M, whereas their ADC values were significantly lower. One reason for the characteristic signal values in diffusion-weighted images of DC may be related to content components such as fibrous tissue and exudate cells. When imaging cystic disease in the head and neck region using SD imaging, the maximum b-value setting at the time of imaging should be limited to approximately 1200 s/mm2 for accurate MK value calculation. This study is the first to show that the MK values of DC are characteristically higher than those of other cysts.

KW - apparent diffusion coefficient value

KW - dentigerous cyst

KW - diffusion kurtosis imaging

KW - head and neck

KW - magnetic resonance imaging

KW - mean kurtosis

KW - simple diffusion kurtosis imaging

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DO - 10.3390/diagnostics13243619

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SN - 2075-4418

VL - 13

JO - Diagnostics

JF - Diagnostics

IS - 24

M1 - 3619

ER -

Characteristic Mean Kurtosis Values in Simple Diffusion Kurtosis Imaging of Dentigerous Cysts

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