Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite

T. Tonegawa; T. Ikoma; T. Yoshioka; G. Chen; N. Hanagata; J. Tanaka

Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite

T. Tonegawa, T. Ikoma, T. Yoshioka, G. Chen, N. Hanagata, J. Tanaka

Research output: Contribution to journal › Article › peer-review

Abstract

The adsorption properties of metal ions containing hydroxyapatite (Ca ₁₀(PO₄)₆(OH)₂, HAp) were elucidated for the development of protein drug carrier. As-prepared metal ion containing HAp nanocrystal showed plate-like morphology with 10-20nm in length and 5-10nm in width. The metal ion containing HAp microparticles had higher specific surface area than the HAp microparticle. The adsorption amount per unit area of HAp showed higher than those of metal ion containing HAp. The adsorption behavior followed the Langmuir curves for each protein, indicating the monolayer adsorption. The loaded amount of proteins could be one of the most important properties for the application of drug delivery carrier.

Original language	English
Pages (from-to)	187-190
Number of pages	4
Journal	Key Engineering Materials
Volume	361-363 I
Publication status	Published - Jan 1 2008
Externally published	Yes

Keywords

Drug delivery system
Hydroxyapatite
Iron
Magnesium
Nanocrystal
Proteins adsorption
Spray drying method
Zinc

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite",

abstract = "The adsorption properties of metal ions containing hydroxyapatite (Ca 10(PO4)6(OH)2, HAp) were elucidated for the development of protein drug carrier. As-prepared metal ion containing HAp nanocrystal showed plate-like morphology with 10-20nm in length and 5-10nm in width. The metal ion containing HAp microparticles had higher specific surface area than the HAp microparticle. The adsorption amount per unit area of HAp showed higher than those of metal ion containing HAp. The adsorption behavior followed the Langmuir curves for each protein, indicating the monolayer adsorption. The loaded amount of proteins could be one of the most important properties for the application of drug delivery carrier.",

keywords = "Drug delivery system, Hydroxyapatite, Iron, Magnesium, Nanocrystal, Proteins adsorption, Spray drying method, Zinc",

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pages = "187--190",

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TY - JOUR

T1 - Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite

AU - Tonegawa, T.

AU - Ikoma, T.

AU - Yoshioka, T.

AU - Chen, G.

AU - Hanagata, N.

AU - Tanaka, J.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The adsorption properties of metal ions containing hydroxyapatite (Ca 10(PO4)6(OH)2, HAp) were elucidated for the development of protein drug carrier. As-prepared metal ion containing HAp nanocrystal showed plate-like morphology with 10-20nm in length and 5-10nm in width. The metal ion containing HAp microparticles had higher specific surface area than the HAp microparticle. The adsorption amount per unit area of HAp showed higher than those of metal ion containing HAp. The adsorption behavior followed the Langmuir curves for each protein, indicating the monolayer adsorption. The loaded amount of proteins could be one of the most important properties for the application of drug delivery carrier.

AB - The adsorption properties of metal ions containing hydroxyapatite (Ca 10(PO4)6(OH)2, HAp) were elucidated for the development of protein drug carrier. As-prepared metal ion containing HAp nanocrystal showed plate-like morphology with 10-20nm in length and 5-10nm in width. The metal ion containing HAp microparticles had higher specific surface area than the HAp microparticle. The adsorption amount per unit area of HAp showed higher than those of metal ion containing HAp. The adsorption behavior followed the Langmuir curves for each protein, indicating the monolayer adsorption. The loaded amount of proteins could be one of the most important properties for the application of drug delivery carrier.

KW - Drug delivery system

KW - Hydroxyapatite

KW - Iron

KW - Magnesium

KW - Nanocrystal

KW - Proteins adsorption

KW - Spray drying method

KW - Zinc

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SN - 1013-9826

VL - 361-363 I

SP - 187

EP - 190

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite

Abstract

Keywords

ASJC Scopus subject areas

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