Chemical modification of lipase for rational enhancement of enantioselectivity

Tadashi Ema, Hiroki Inoue

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Chemical modifications of the I287C mutant of a Burkholderia cepacia lipase afforded various I287C-X conjugates, among which I287C-PAA bearing an N-phenylacetamide (PAA) moiety showed excellent enantioselectivity and catalytic activity for secondary alcohols. Site-directed chemical modifications are powerful tools to control enantioselective biocatalysis.

Original languageEnglish
Pages (from-to)1374-1376
Number of pages3
JournalChemistry Letters
Issue number10
Publication statusPublished - 2015

ASJC Scopus subject areas

  • General Chemistry


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