Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste

Benjamas Thanomsub; Wanna Pumeechockchai; Anirut Limtrakul; Panarat Arunrattiyakorn; Wipawan Petchleelaha; Teruhiko Nitoda; Hiroshi Kanzaki

doi:10.1016/j.biortech.2005.10.045

Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste

Benjamas Thanomsub, Wanna Pumeechockchai, Anirut Limtrakul, Panarat Arunrattiyakorn, Wipawan Petchleelaha, Teruhiko Nitoda, Hiroshi Kanzaki

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The aim of this work was to study chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste. The culture produced two biosurfactants, a and b, which showed strong activity and were identified as l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydecanoate or Rha-Rha-C₁₀-C₁₀ and l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydodecanoate or Rha-Rha-C₁₀-C₁₂, respectively. Both compounds exhibited higher surfactant activities tested by the drop collapse test than several artificial surfactants such as SDS and Tween 80. Rhamnolipid a showed significant antiproliferative activity against human breast cancer cell line (MCF-7) at minimum inhibitory concentration (MIC) at 6.25 μg/mL while rhamnolipid b showed MIC against insect cell line C6/36 at 50 μg/mL.

Original language	English
Pages (from-to)	1149-1153
Number of pages	5
Journal	Bioresource Technology
Volume	98
Issue number	5
DOIs	https://doi.org/10.1016/j.biortech.2005.10.045
Publication status	Published - Mar 2007

Keywords

Anticancer
Biological activity
Biosurfactant
Glycolipid
Pseudomonas
Rhamnolipid

ASJC Scopus subject areas

Bioengineering
Environmental Engineering
Renewable Energy, Sustainability and the Environment
Waste Management and Disposal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biortech.2005.10.045

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title = "Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste",

abstract = "The aim of this work was to study chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste. The culture produced two biosurfactants, a and b, which showed strong activity and were identified as l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydecanoate or Rha-Rha-C10-C10 and l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydodecanoate or Rha-Rha-C10-C12, respectively. Both compounds exhibited higher surfactant activities tested by the drop collapse test than several artificial surfactants such as SDS and Tween 80. Rhamnolipid a showed significant antiproliferative activity against human breast cancer cell line (MCF-7) at minimum inhibitory concentration (MIC) at 6.25 μg/mL while rhamnolipid b showed MIC against insect cell line C6/36 at 50 μg/mL.",

keywords = "Anticancer, Biological activity, Biosurfactant, Glycolipid, Pseudomonas, Rhamnolipid",

author = "Benjamas Thanomsub and Wanna Pumeechockchai and Anirut Limtrakul and Panarat Arunrattiyakorn and Wipawan Petchleelaha and Teruhiko Nitoda and Hiroshi Kanzaki",

year = "2007",

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doi = "10.1016/j.biortech.2005.10.045",

language = "English",

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AU - Thanomsub, Benjamas

AU - Pumeechockchai, Wanna

AU - Limtrakul, Anirut

AU - Arunrattiyakorn, Panarat

AU - Petchleelaha, Wipawan

AU - Nitoda, Teruhiko

AU - Kanzaki, Hiroshi

PY - 2007/3

Y1 - 2007/3

N2 - The aim of this work was to study chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste. The culture produced two biosurfactants, a and b, which showed strong activity and were identified as l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydecanoate or Rha-Rha-C10-C10 and l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydodecanoate or Rha-Rha-C10-C12, respectively. Both compounds exhibited higher surfactant activities tested by the drop collapse test than several artificial surfactants such as SDS and Tween 80. Rhamnolipid a showed significant antiproliferative activity against human breast cancer cell line (MCF-7) at minimum inhibitory concentration (MIC) at 6.25 μg/mL while rhamnolipid b showed MIC against insect cell line C6/36 at 50 μg/mL.

AB - The aim of this work was to study chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste. The culture produced two biosurfactants, a and b, which showed strong activity and were identified as l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydecanoate or Rha-Rha-C10-C10 and l-rhamnopyranosyl-l-rhamnopyranosyl-β-hydroxydecanoyl-β-hydroxydodecanoate or Rha-Rha-C10-C12, respectively. Both compounds exhibited higher surfactant activities tested by the drop collapse test than several artificial surfactants such as SDS and Tween 80. Rhamnolipid a showed significant antiproliferative activity against human breast cancer cell line (MCF-7) at minimum inhibitory concentration (MIC) at 6.25 μg/mL while rhamnolipid b showed MIC against insect cell line C6/36 at 50 μg/mL.

KW - Anticancer

KW - Biological activity

KW - Biosurfactant

KW - Glycolipid

KW - Pseudomonas

KW - Rhamnolipid

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Chemical structures and biological activities of rhamnolipids produced by Pseudomonas aeruginosa B189 isolated from milk factory waste

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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