Chemokines in granulomatous lung inflammation

Stephen W. Chensue, Akihiro Matsukawa, Cory M. Hogaboam, Steven L. Kunkel

Research output: Chapter in Book/Report/Conference proceedingChapter


The clinical manifestations of pulmonary granulomatous diseases are usually the consequence of long-term leukocyte elicitation and activation, resulting in chronic tissue inflammation and lung injury (1). Most interstitial granulomatous diseases in the lung are difficult to treat, requiring therapies that may seriously compromise the immunologic and physiologic integrity of the patient. Historically, the therapeutic approach to the treatment of infectious granulomatous disease has been to target the known infectious agent, while treatment of idiopathic granulomatous diseases has usually targeted immune/inflammatory cell function. Once the pulmonary disease is diagnosed, antimicrobial agents are used to treat the former, while immunosuppressive agents are usually used to treat the latter disease states (2,3). Unfortunately, the clinical management of these diseases does not necessarily ablate the subsequent pathology, which is observed in certain patients. This is especially true in difficult clinical cases, such as drug-resistant mycobacterial diseases or progressive sarcoidosis refractory to corticosteroids (2). Thus, the limited therapeutic options, which are available to effectively manage patients with granulomatous lung disease, may reflect the limited understanding of the mechanisms underlying these chronic diseases.

Original languageEnglish
Title of host publicationChemokines in the Lung
PublisherCRC Press
Number of pages17
ISBN (Electronic)9780824747442
ISBN (Print)9780824708580
Publication statusPublished - Jan 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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