TY - JOUR
T1 - Chemosensitive neurons within the area postrema of the rat
AU - Adachi, Akira
AU - Kobashi, Motoi
N1 - Funding Information:
encouragement of the project. We also thank Miss Kahori Hirata for typing the manuscript. This work was supported by a research grant from the Ministry of Education of Japan.
PY - 1985/4/9
Y1 - 1985/4/9
N2 - It is demonstrated that some neurons within the area postrema, if not all, are responsive to glucose or sodium ions applied topically by means of microelectro-osmotic techniques. Glucose-responsive neurons displayed a marked decrease in the discharge rate in response to the topical application of glucose. Two different types of sodium-responsive neurons were observed; one was characterized by increasing the frequency of the discharges responding to microiontophoretic application of Na+, while the other showed the opposite response by decreasing the discharge rate in response to the same stimulation. They may serve enteroceptors in response to changes in the glucose or sodium concentrations of cerebrospinal fluid (CSF) or blood.
AB - It is demonstrated that some neurons within the area postrema, if not all, are responsive to glucose or sodium ions applied topically by means of microelectro-osmotic techniques. Glucose-responsive neurons displayed a marked decrease in the discharge rate in response to the topical application of glucose. Two different types of sodium-responsive neurons were observed; one was characterized by increasing the frequency of the discharges responding to microiontophoretic application of Na+, while the other showed the opposite response by decreasing the discharge rate in response to the same stimulation. They may serve enteroceptors in response to changes in the glucose or sodium concentrations of cerebrospinal fluid (CSF) or blood.
KW - area postrema
KW - glucose-responsive neuron
KW - sodium-responsive neuron
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U2 - 10.1016/0304-3940(85)90008-4
DO - 10.1016/0304-3940(85)90008-4
M3 - Article
C2 - 4000542
AN - SCOPUS:0021999537
SN - 0304-3940
VL - 55
SP - 137
EP - 140
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -