TY - JOUR
T1 - Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)
AU - Kawashima, Nozomu
AU - Shimada, Akira
AU - Taketani, Takeshi
AU - Hayashi, Yasuhide
AU - Yoshida, Nao
AU - Matsumoto, Kimikazu
AU - Takahashi, Yoshiyuki
AU - Kojima, Seiji
AU - Kato, Koji
PY - 2012/5
Y1 - 2012/5
N2 - Acute myeloid leukemia with abnormal bone marrow eosinophilia (AML-M4Eo) is often reported in core binding factor (CBF) leukemia, with translocations such as inv(16)(p13q22), t(16;16)(p13;q22) or t(8;21)(q22;q22); however, it is rarely reported with t(16;21)(q24;q22), which produces the RUNX1-CBFA2T3 (AML1-MTG16) chimera. The similarity between this chimera and RUNX1-RUNXT1 (AML1-MTG8) by t(8;21)(q22;q22) remains controversial. Adult leukemia with t(16;21)(q24;q22) was primarily therapy related, and shows poor prognosis; however, pediatric AML with this translocation was quite rare and tended to be de novo AML. We present here a 4-year-old boy with de novo AML-M4Eo and t(16;21) (q24;q22). He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22).
AB - Acute myeloid leukemia with abnormal bone marrow eosinophilia (AML-M4Eo) is often reported in core binding factor (CBF) leukemia, with translocations such as inv(16)(p13q22), t(16;16)(p13;q22) or t(8;21)(q22;q22); however, it is rarely reported with t(16;21)(q24;q22), which produces the RUNX1-CBFA2T3 (AML1-MTG16) chimera. The similarity between this chimera and RUNX1-RUNXT1 (AML1-MTG8) by t(8;21)(q22;q22) remains controversial. Adult leukemia with t(16;21)(q24;q22) was primarily therapy related, and shows poor prognosis; however, pediatric AML with this translocation was quite rare and tended to be de novo AML. We present here a 4-year-old boy with de novo AML-M4Eo and t(16;21) (q24;q22). He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22).
KW - AML
KW - Eosinophilia
KW - Pediatric
KW - RUNX1-CBFA2T3
KW - t(16;21)(q24;q22)
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UR - http://www.scopus.com/inward/citedby.url?scp=84862897867&partnerID=8YFLogxK
U2 - 10.1007/s12185-012-1044-7
DO - 10.1007/s12185-012-1044-7
M3 - Article
C2 - 22403058
AN - SCOPUS:84862897867
SN - 0925-5710
VL - 95
SP - 577
EP - 580
JO - International journal of hematology
JF - International journal of hematology
IS - 5
ER -