TY - JOUR
T1 - Childhood-onset epilepsy associated with polymicrogyria
AU - Ohtsuka, Yoko
AU - Tanaka, Akio
AU - Kobayashi, Katsuhiro
AU - Ohta, Hodaka
AU - Abiru, Kiyoko
AU - Nakano, Kohsuke
AU - Oka, Eiji
N1 - Funding Information:
This study was supported in part by a research grant (7 Shi-1) for Nervous and Mental Disorders from the Ministry of Health and Welfare, Japan.
PY - 2002/12
Y1 - 2002/12
N2 - To study the electroclinical characteristics of patients with childhood-onset epilepsy who showed polymicrogyria (PMG) on MRI, we classified 15 patients according to the location of PMG on MRI. The composition of the subjects was as follows: four patients with PMG in both hemispheres; three with localized PMG in one hemisphere associated with other lesions such as porencephaly; and eight with only localized PMG in one hemisphere. We investigated the electroclinical characteristics of the epileptic syndromes associated with these different types of PMG. Four patients suffered from infantile spasms during their clinical course. Five patients suffered from epilepsy with electrical status epilepticus during slow sleep (ESES) and ESES-related epilepsy. The other six patients had only localization-related epilepsy throughout their clinical course. Patients with PMG in both hemispheres, and localized PMG in one hemisphere associated with other lesions tended to have early-onset intractable seizures, especially infantile spasms. On the other hand, patients with only localized PMG in one hemisphere had ESES and ESES-related epilepsy or localization-related epilepsy, and their seizure prognosis was relatively favorable. These findings are useful in predicting the outcome of patients with PMG.
AB - To study the electroclinical characteristics of patients with childhood-onset epilepsy who showed polymicrogyria (PMG) on MRI, we classified 15 patients according to the location of PMG on MRI. The composition of the subjects was as follows: four patients with PMG in both hemispheres; three with localized PMG in one hemisphere associated with other lesions such as porencephaly; and eight with only localized PMG in one hemisphere. We investigated the electroclinical characteristics of the epileptic syndromes associated with these different types of PMG. Four patients suffered from infantile spasms during their clinical course. Five patients suffered from epilepsy with electrical status epilepticus during slow sleep (ESES) and ESES-related epilepsy. The other six patients had only localization-related epilepsy throughout their clinical course. Patients with PMG in both hemispheres, and localized PMG in one hemisphere associated with other lesions tended to have early-onset intractable seizures, especially infantile spasms. On the other hand, patients with only localized PMG in one hemisphere had ESES and ESES-related epilepsy or localization-related epilepsy, and their seizure prognosis was relatively favorable. These findings are useful in predicting the outcome of patients with PMG.
KW - Cortical malformation
KW - Epilepsy with continuous spike-waves during slow wave sleep
KW - Epileptic spasms
KW - Infantile spasms
KW - Polymicrogyria
KW - Prognosis
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U2 - 10.1016/S0387-7604(02)00099-2
DO - 10.1016/S0387-7604(02)00099-2
M3 - Article
C2 - 12453599
AN - SCOPUS:0036891355
SN - 0387-7604
VL - 24
SP - 758
EP - 765
JO - Brain and Development
JF - Brain and Development
IS - 8
ER -