We have succeeded in introducing a chiral auxiliary tethered by an appropriate metal into the hydroxy group of N-benzylhydroxylamine. The thus-obtained recyclable chiral reagent can act as an amine nucleophile to give chiral isoxazolidinones (up to 71% ee) as a β-amino acid synthon on the reaction with α,β-unsaturated carbonyl compounds.
|Number of pages||3|
|Publication status||Published - Nov 1998|
ASJC Scopus subject areas
- Organic Chemistry