Chiral scandium-catalyzed enantioselective hydroxymethylation of ketones in water

Shu Kobayashi; Masaya Kokubo; Katsuaki Kawasumi; Takashi Nagano

doi:10.1002/asia.200900442

Chiral scandium-catalyzed enantioselective hydroxymethylation of ketones in water

Shu Kobayashi, Masaya Kokubo, Katsuaki Kawasumi, Takashi Nagano

Research Core for Interdisciplinary Sciences

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60 Citations (Scopus)

Abstract

Scandium-catalyzed enantioselective hydroxymethylation of ketones has been developed using aqueous formaldehyde (formalin) in water. The addition of a catalytic amount of pyridine enables the use of ketones directly in asymmetric hydroxymethylation reactions. (Chemical equation presented).

Original language	English
Pages (from-to)	490-492
Number of pages	3
Journal	Chemistry - An Asian Journal
Volume	5
Issue number	3
DOIs	https://doi.org/10.1002/asia.200900442
Publication status	Published - Mar 1 2010

Keywords

Asymmetric catalysis
Green chemistry
Hydroxymethylation
Scandium
Water

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1002/asia.200900442

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abstract = "Scandium-catalyzed enantioselective hydroxymethylation of ketones has been developed using aqueous formaldehyde (formalin) in water. The addition of a catalytic amount of pyridine enables the use of ketones directly in asymmetric hydroxymethylation reactions. (Chemical equation presented).",

keywords = "Asymmetric catalysis, Green chemistry, Hydroxymethylation, Scandium, Water",

author = "Shu Kobayashi and Masaya Kokubo and Katsuaki Kawasumi and Takashi Nagano",

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AU - Kobayashi, Shu

AU - Kokubo, Masaya

AU - Kawasumi, Katsuaki

AU - Nagano, Takashi

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Scandium-catalyzed enantioselective hydroxymethylation of ketones has been developed using aqueous formaldehyde (formalin) in water. The addition of a catalytic amount of pyridine enables the use of ketones directly in asymmetric hydroxymethylation reactions. (Chemical equation presented).

AB - Scandium-catalyzed enantioselective hydroxymethylation of ketones has been developed using aqueous formaldehyde (formalin) in water. The addition of a catalytic amount of pyridine enables the use of ketones directly in asymmetric hydroxymethylation reactions. (Chemical equation presented).

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KW - Green chemistry

KW - Hydroxymethylation

KW - Scandium

KW - Water

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M3 - Article

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ER -

Chiral scandium-catalyzed enantioselective hydroxymethylation of ketones in water

Abstract

Keywords

ASJC Scopus subject areas

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