Chronic administration of oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

Hideaki Kabuto; Masato Asanuma; Sakiko Nishibayashi; Motoyuki Lida; Norio Ogawa

doi:10.1023/a:1027369119224

Chronic administration of oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

Hideaki Kabuto, Masato Asanuma, Sakiko Nishibayashi, Motoyuki Lida, Norio Ogawa

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	Neurochemical Research
Volume	22
Issue number	1
DOIs	https://doi.org/10.1023/a:1027369119224
Publication status	Published - 1997

Keywords

Acctylcholine
Monoamine metabolism
Muscarinic receptor
Oren-gedoku-to (TJ15)
Serotonin
Transient ischemia

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1023/a:1027369119224

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title = "Chronic administration of oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil",

abstract = "We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.",

keywords = "Acctylcholine, Monoamine metabolism, Muscarinic receptor, Oren-gedoku-to (TJ15), Serotonin, Transient ischemia",

author = "Hideaki Kabuto and Masato Asanuma and Sakiko Nishibayashi and Motoyuki Lida and Norio Ogawa",

note = "Funding Information: This work was supported by a Grant-in-Aid for Research Projects on Aging and Health from the Japanese Ministry of Health and Welfare.",

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T1 - Chronic administration of oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

AU - Kabuto, Hideaki

AU - Asanuma, Masato

AU - Nishibayashi, Sakiko

AU - Lida, Motoyuki

AU - Ogawa, Norio

N1 - Funding Information: This work was supported by a Grant-in-Aid for Research Projects on Aging and Health from the Japanese Ministry of Health and Welfare.

PY - 1997

Y1 - 1997

N2 - We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

AB - We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

KW - Acctylcholine

KW - Monoamine metabolism

KW - Muscarinic receptor

KW - Oren-gedoku-to (TJ15)

KW - Serotonin

KW - Transient ischemia

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Chronic administration of oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the mongolian gerbil

Abstract

Keywords

ASJC Scopus subject areas

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