Chronic kidney disease is associated with carotid atherosclerosis and symptomatic ischaemic stroke

Nobuo Kajitani, Haruhito A. Uchida, Isao Suminoe, Yuki Kakio, Masashi Kitagawa, Hajime Sato, Jun Wada

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Objective: We aimed to investigate the relationships among chronic kidney disease (CKD), symptomatic ischaemic stroke, and carotid atherosclerosis. Methods: We enrolled 455 patients who underwent carotid ultrasonography in our hospital, including 311 patients with symptomatic ischaemic stroke and 144 patients without symptomatic ischaemic stroke. Carotid intima–media thickness (IMT), the rate of internal carotid artery stenosis, and maximal plaque size were evaluated. Results: The mean age of the patients was 68.5 ± 11.0 years and the mean estimated glomerular filtration rate (eGFR) was 68.8 ± 18.2 mL/min/1.73 m 2 . After adjustment for cardiovascular risk factors, the mean IMT was significantly higher in patients with CKD than in those without CKD. The IMT and eGFR were negatively correlated in patients with stroke (r = −0.169). Multiple logistic regression analyses showed that mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischaemic stroke after adjustment of multivariate risk factors. Furthermore, the eGFR was a negative determinant of symptomatic ischaemic stroke after adjusting for classical risk factors (odds ratio [95% confidence interval] = 0.868 [0.769–0.979]). Conclusion: CKD might be associated with the carotid atherosclerosis and symptomatic ischaemic stroke.

Original languageEnglish
Pages (from-to)3873-3883
Number of pages11
JournalJournal of International Medical Research
Issue number9
Publication statusPublished - Sept 1 2018


  • Chronic kidney disease (CKD)
  • carotid atherosclerosis
  • glomerular filtration rate (GFR)
  • intima–media thickness (IMT)
  • ischaemic stroke
  • ultrasonography

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, medical
  • Cell Biology


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