Chronic lymphoproliferative disorder with regulatory T-cell phenotype

Tomoko Kikuchi; Yoshio Katayama; Shiro Kubonishi; Toshiyuki Watanabe; Yukari Watanabe; Ken Ichi Matsuoka; Yoshinobu Maeda; Noriko Namba; Taro Masunari; Ryusuke Nasu; Kazuma Ikeda; Mitsune Tanimoto

doi:10.1002/ajh.20688

Chronic lymphoproliferative disorder with regulatory T-cell phenotype

Tomoko Kikuchi, Yoshio Katayama, Shiro Kubonishi, Toshiyuki Watanabe, Yukari Watanabe, Ken Ichi Matsuoka, Yoshinobu Maeda, Noriko Namba, Taro Masunari, Ryusuke Nasu, Kazuma Ikeda, Mitsune Tanimoto

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.

Original language	English
Pages (from-to)	713-716
Number of pages	4
Journal	American Journal of Hematology
Volume	81
Issue number	9
DOIs	https://doi.org/10.1002/ajh.20688
Publication status	Published - Sept 2006

Keywords

Chronic lymphoproliferative disorder
Foxp3
Regulatory T cells

ASJC Scopus subject areas

Hematology

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10.1002/ajh.20688

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title = "Chronic lymphoproliferative disorder with regulatory T-cell phenotype",

abstract = "We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.",

keywords = "Chronic lymphoproliferative disorder, Foxp3, Regulatory T cells",

author = "Tomoko Kikuchi and Yoshio Katayama and Shiro Kubonishi and Toshiyuki Watanabe and Yukari Watanabe and Matsuoka, {Ken Ichi} and Yoshinobu Maeda and Noriko Namba and Taro Masunari and Ryusuke Nasu and Kazuma Ikeda and Mitsune Tanimoto",

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T1 - Chronic lymphoproliferative disorder with regulatory T-cell phenotype

AU - Kikuchi, Tomoko

AU - Katayama, Yoshio

AU - Kubonishi, Shiro

AU - Watanabe, Toshiyuki

AU - Watanabe, Yukari

AU - Matsuoka, Ken Ichi

AU - Maeda, Yoshinobu

AU - Namba, Noriko

AU - Masunari, Taro

AU - Nasu, Ryusuke

AU - Ikeda, Kazuma

AU - Tanimoto, Mitsune

PY - 2006/9

Y1 - 2006/9

N2 - We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.

AB - We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene for developmental differentiation of regulatory T cells (Treg), was confirmed at mRNA and protein levels. To our knowledge, this is the first case of extremely indolent CLPD with Treg phenotype.

KW - Chronic lymphoproliferative disorder

KW - Foxp3

KW - Regulatory T cells

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Chronic lymphoproliferative disorder with regulatory T-cell phenotype

Abstract

Keywords

ASJC Scopus subject areas

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