Clinical and pathological aspects of hemophilia a in Japanese Brown cattle

Yasuo Moritomo, Kenichi Shimojo, Keiko Miyadera, Maryam Khalaj, Yuka Asano, Tetsuo Kunieda, Hiroyuki Ogawa

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A coagulopathy with subcutaneous bleeding and muscular or peritracheal/periesophageal bleeding occurred in two male Japanese Brown calves of the same dam. One of the affected calves died three days after the onset of bleeding and the other survived normally until being slaughtered despite once suffering from subcutaneous hematoma. Hemostatic tests of the latter case showed prolonged activated partial thromboplastin time (APTT), and severely reduced factor VIII activity. In addition, von Willebrand factor activity, determined by the human platelet aggregation test, was within the normal range; therefore, the calf was diagnosed with hemophilia A. These are the first bovine cases of hemophilia A definitely diagnosed clinicopathologically.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number3
Publication statusPublished - Mar 2008


  • Factor VIII
  • Hemophilia A
  • Japanese Brown cattle

ASJC Scopus subject areas

  • General Veterinary


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