TY - JOUR
T1 - [Clinical assessment of granulocyte colony-stimulating factor producing lung cancer].
AU - Matsuda, Eisuke
AU - Okabe, Kazunori
AU - Tao, Hiroyuki
AU - Yamamoto, Hiromasa
AU - Hirazawa, Katsutoshi
AU - Kobayashi, Seiki
AU - Murakami, Tomoyuki
AU - Sugi, Kazuro
N1 - Copyright:
MEDLINE® is the source for the citation and abstract of this record.
PY - 2011/6
Y1 - 2011/6
N2 - The aim of this study was to reveal the clinicopathological feature of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. Nine cases of G-CSF producing lung cancer from July 2003 to July 2008 were retrospectively evaluated. All cases were male, 8 cases were poorly differentiated carcinoma. Average of leucocyte and serum G-CSF were 23,378/microl and 128.6 pg/ml respectively. Five cases had febrile symptom, average of serum C-reactive protein (CRP) was 13.37 mg/dl. Immunohistological examination showed positive staining for G-CSF in 6 cases. Serum interleukin-6 (IL-6) level was elevated in 3 cases. Clinical stages were IB in 2, IIB in 2, IIIA in 3 and IIIB in 2 patients. Chemotherapy was performed for patients with stage IIIB. Operation was performed for the other cases. Five cases were died within 12 months, whereas 4 cases are surviving for 6 to 16 months. Generally, the prognosis of G-CSF producing lung cancer seems to be poor, but in our institute there were 2 cases who lived over 1 year without disease. It is important to establish more effective adjuvant therapy for G-CSF producing tumor.
AB - The aim of this study was to reveal the clinicopathological feature of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. Nine cases of G-CSF producing lung cancer from July 2003 to July 2008 were retrospectively evaluated. All cases were male, 8 cases were poorly differentiated carcinoma. Average of leucocyte and serum G-CSF were 23,378/microl and 128.6 pg/ml respectively. Five cases had febrile symptom, average of serum C-reactive protein (CRP) was 13.37 mg/dl. Immunohistological examination showed positive staining for G-CSF in 6 cases. Serum interleukin-6 (IL-6) level was elevated in 3 cases. Clinical stages were IB in 2, IIB in 2, IIIA in 3 and IIIB in 2 patients. Chemotherapy was performed for patients with stage IIIB. Operation was performed for the other cases. Five cases were died within 12 months, whereas 4 cases are surviving for 6 to 16 months. Generally, the prognosis of G-CSF producing lung cancer seems to be poor, but in our institute there were 2 cases who lived over 1 year without disease. It is important to establish more effective adjuvant therapy for G-CSF producing tumor.
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M3 - Article
C2 - 21682039
AN - SCOPUS:79960591237
SN - 0021-5252
VL - 64
SP - 445
EP - 449
JO - Kyobu geka. The Japanese journal of thoracic surgery
JF - Kyobu geka. The Japanese journal of thoracic surgery
IS - 6
ER -
