Clinical characteristics of elderly depressive patients with low metaiodobenzylguanidine uptake

Shintaro Takenoshita, Seishi Terada, Etsuko Oshima, Megumi Yamaguchi, Satoshi Hayashi, Kenji Hinotsu, Satoru Esumi, Takayoshi Shinya, Norihito Yamada

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Recently, depression with Lewy body pathology before the appearance of parkinsonism and cognitive dysfunction has been drawing attention. Low cardiac metaiodobenzylguanidine (MIBG) uptake is helpful for early differentiation of Lewy body disease (LBD) from late-onset psychiatric disorders even before parkinsonism or dementia appears. In this study, we used MIBG uptake as a tool in suspected LBD, and evaluated the relationship of MIBG results to clinical characteristics and depressive symptoms. Methods: Fifty-two elderly inpatients with depression were included in this study. The Hamilton Depression Rating Scale (HDRS) was administered at admission, and 123I-MIBG cardiac scintigraphy was performed. Of 52 patients, 38 had normal and 14 had reduced MIBG uptake. Results: Correlation analyses of the late phase heart-to-mediastinum (H/M) ratio on the MIBG test and each item of the HDRS revealed that the H/M ratio was significantly correlated with scores of ‘agitation’, ‘anxiety-somatic’, and ‘retardation’ on the HDRS. Mean HDRS composite scores of ‘somatic and psychic anxiety (Marcos)’ and ‘somatic anxiety/somatization factor (Pancheri)’ were higher in the low uptake group than in the normal uptake group. Conclusion: Elderly patients with depression who manifested an obvious somatic anxiety tend to show low MIBG uptake, and are more likely to have Lewy body pathology.

Original languageEnglish
Pages (from-to)566-573
Number of pages8
Issue number6
Publication statusPublished - Nov 1 2019


  • Lewy body disease
  • depression
  • elderly
  • metaiodobenzylguanidine
  • somatic anxiety

ASJC Scopus subject areas

  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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