Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration

Mitsuko Yuzawa; Shin Yoneya; Masanobu Uyama; Kanji Takahashi; Muneyasu Takeda; Fumio Shiraga; Tokuhiko Miki; Kunihiko Shiraki; Kazuhiko Hayashi; Yuichiro Ogura; Sadao Komemushi; Mizuo Matsui

Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration

Mitsuko Yuzawa, Shin Yoneya, Masanobu Uyama, Kanji Takahashi, Muneyasu Takeda, Fumio Shiraga, Tokuhiko Miki, Kunihiko Shiraki, Kazuhiko Hayashi, Yuichiro Ogura, Sadao Komemushi, Mizuo Matsui

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). SUBJECTS AND METHODS: Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. RESULTS: Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. CONCLUSION: A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.

Original language	English
Pages (from-to)	89-98
Number of pages	10
Journal	Nippon Ganka Gakkai zasshi
Volume	106
Issue number	2
Publication status	Published - Feb 2002
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration",

abstract = "PURPOSE: To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). SUBJECTS AND METHODS: Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. RESULTS: Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. CONCLUSION: A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.",

author = "Mitsuko Yuzawa and Shin Yoneya and Masanobu Uyama and Kanji Takahashi and Muneyasu Takeda and Fumio Shiraga and Tokuhiko Miki and Kunihiko Shiraki and Kazuhiko Hayashi and Yuichiro Ogura and Sadao Komemushi and Mizuo Matsui",

year = "2002",

month = feb,

language = "English",

volume = "106",

pages = "89--98",

journal = "Nippon Ganka Gakkai zasshi",

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publisher = "Nippon Ganka Gakkai",

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TY - JOUR

T1 - Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration

AU - Yuzawa, Mitsuko

AU - Yoneya, Shin

AU - Uyama, Masanobu

AU - Takahashi, Kanji

AU - Takeda, Muneyasu

AU - Shiraga, Fumio

AU - Miki, Tokuhiko

AU - Shiraki, Kunihiko

AU - Hayashi, Kazuhiko

AU - Ogura, Yuichiro

AU - Komemushi, Sadao

AU - Matsui, Mizuo

PY - 2002/2

Y1 - 2002/2

N2 - PURPOSE: To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). SUBJECTS AND METHODS: Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. RESULTS: Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. CONCLUSION: A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.

AB - PURPOSE: To evaluate the proper clinical dosage of indocyanine green(ICG) in angiography for detecting choroidal neovascularization(CNV) of exudative age-related macular degeneration(AMD). SUBJECTS AND METHODS: Indocyanine green angiography (IA) was performed using a randomized crossover method with two different doses on two occasions. Ease of detection, side effects and clinical serum data were also evaluated. RESULTS: Among the 39 eyes, detection of CNV using 12.5 mg and 25 mg was most effective in 21 and 31 eyes respectively, showing a statistically significant difference. Slight vomiting was observed temporarily in one patient who had taken 25 mg. CONCLUSION: A dose of 25 mg is appropriate for detection of CNV of exudative AMD and this dosage raises no safety concerns.

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M3 - Article

C2 - 11915378

AN - SCOPUS:0036485064

SN - 0029-0203

VL - 106

SP - 89

EP - 98

JO - Nippon Ganka Gakkai zasshi

JF - Nippon Ganka Gakkai zasshi

IS - 2

ER -

Clinical dose finding study of indocyanine green to detect choroidal neovascularization in patients with exudative age-related macular degeneration

Abstract

ASJC Scopus subject areas

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