Clinical Effect of Low-Dose, Long-Term Roxithromycin Chemotherapy in Patients with Chronic Sinusitis

Nobuhiko Kimura; Keiko Nishioka; Kazunori Nishizaki; Teruhiro Ogawa; Yoshihiro Naitou; Yu Masuda

Clinical Effect of Low-Dose, Long-Term Roxithromycin Chemotherapy in Patients with Chronic Sinusitis

Nobuhiko Kimura, Keiko Nishioka, Kazunori Nishizaki, Teruhiro Ogawa, Yoshihiro Naitou, Yu Masuda

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the clinical efficacy of roxithromycin (RXM) administered at the daily dosage of one tablet (150mg) for 3 months in 30 patients with chronic sinusitis. The effectiveness of this drug was evaluated on a four-point scale. Subjective and objective symptoms disappeared or decreased markedly, especially postnasal drip and nature of discharge in 80 percent or more of the patients. All symptoms significantly decreased (P < 0.001; headache P < 0.05), except for the sensation of foul odor. Symptoms improved even in those cases in which Haemophilus influenzae was detected. It is suggested that RXM produces some clinically beneficial effect through an immunological and or anti-inflammatory mechanisms in addition to its antibiotic effect.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	Acta medica Okayama
Volume	51
Issue number	1
Publication status	Published - Feb 1 1997

Keywords

Chronic sinusitis
Clinical evaluation
Long-term
Low-dose administration
Roxithromycin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "We studied the clinical efficacy of roxithromycin (RXM) administered at the daily dosage of one tablet (150mg) for 3 months in 30 patients with chronic sinusitis. The effectiveness of this drug was evaluated on a four-point scale. Subjective and objective symptoms disappeared or decreased markedly, especially postnasal drip and nature of discharge in 80 percent or more of the patients. All symptoms significantly decreased (P < 0.001; headache P < 0.05), except for the sensation of foul odor. Symptoms improved even in those cases in which Haemophilus influenzae was detected. It is suggested that RXM produces some clinically beneficial effect through an immunological and or anti-inflammatory mechanisms in addition to its antibiotic effect.",

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AU - Ogawa, Teruhiro

AU - Naitou, Yoshihiro

AU - Masuda, Yu

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Clinical Effect of Low-Dose, Long-Term Roxithromycin Chemotherapy in Patients with Chronic Sinusitis

Abstract

Keywords

ASJC Scopus subject areas

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