Clinical evaluation of muscle strength in 20-79-years-old obese Japanese

Nobuyuki Miyatake, Masafumi Fujii, Hidetaka Nishikawa, Jun Wada, Kenichi Shikata, Hirofumi Makino, Ikuro Kimura

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


It is well known that obesity is closely related to non-insulin- dependent diabetes mellitus, hyperlipidemia, hypertension and cardiovascular disease, and the insulin resistance associated with obesity is supposed to play a central role for the development of these diseases. Thus, effective prevention and treatment of obesity need to be explored. In 357 obese (body mass index ≥ 26.4) subjects, aged 20-79 years, grip and leg strength were determined and compared with age- and sex-matched 1683 nonobese control subjects. Age-dependent alteration of body composition, evaluated by waist- hip ratio and the relative fat mass volume, was also compared. Finally, the relationship between the number of risk factors related to atherosclerosis and muscle strength was evaluated. Grip and leg strength in obese subjects were obviously stronger than controls under the age of 60 in both sexes. However, in the subjects over 60 years old, muscle strength was similar between obese subjects and controls. Weight bearing index (WBI) (leg strength (kg)/body weight (kg)) in obese subjects was remarkably lower than that in controls in all generations. In obese subjects, the waist-hip ratio and relative percentage of fat increased with aging, and obese subjects with multiple risk factors had higher waist-hip ratio and a tendency for lower muscle strength. Reduced WBI was considered to be a fundamental feature of obese subjects, and obese subjects increased fat composition with aging, which may be linked with low muscle strength. Thus, we need to design the most effective protocols to maximize and maintain quantitative and qualitative properties of muscle. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalDiabetes Research and Clinical Practice
Issue number1
Publication statusPublished - Apr 2000


  • Body composition
  • Grip strength
  • Leg strength
  • Obesity
  • Weight bearing index

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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