Clinical outcome and risk stratification in Brugada syndrome

Tadashi Wada, Hiroshi Morita

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Since the first report on Brugada syndrome, various risk markers for the prediction of ventricular fibrillation (VF) in patients with Brugada syndrome have been reported. Multicenter trials reported spontaneous type 1 electrocardiogram (ECG) and disease symptoms as prognostic predictors. VF induction by programmed electrical stimulation is still controversial, and most of the studies have failed to prove its significance for the prediction of spontaneous VF episodes. In Japan, although most multicenter studies have shown that patients with type 1 ECG were at high risk, it is difficult to determine the indication for implantation of an implantable cardioverter defibrillator only based on the ECG type. Recent studies have added new risk markers, such as inferolateral early repolarization, fragmented QRS, and shorter effective refractory periods of the ventricle, in addition to type 1 ECG and symptoms. Here, we review the clinical outcome and indices reported as reliable prognostic factors of Brugada syndrome with a focus on the clinical and ECG markers for risk stratification.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
Journaljournal of arrhythmia
Issue number2
Publication statusPublished - Apr 2013


  • Brugada syndrome
  • ECG
  • Risk stratification
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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