TY - JOUR
T1 - Clinicopathologic analysis of gastric mucosa-associated lymphoid tissue lymphoma with or without c-Met expression
AU - Omote, Rika
AU - Gion, Yuka
AU - Omote, Shizuma
AU - Tari, Akira
AU - Tanaka, Takehiro
AU - Nishikori, Asami
AU - Yoshino, Tadashi
AU - Sato, Yasuharu
N1 - Publisher Copyright:
© 2020, The Japanese Society for Clinical Molecular Morphology.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach is mainly associated with Helicobacter pylori infection, and H. pylori eradication therapy is often effective. However, 20–30% of the cases of MALT lymphoma are resistant to the eradication therapy, and translocation of the API2-MALT1 gene is often found in these cases. Most cases without translocation of API2-MALT1 are localized to the stomach, whereas some cases with this translocation are a more advanced stage of MALT lymphoma that spreads to other organs. The c-Met receptor is a prognostic factor involved in infiltration and metastasis in many malignant tumors, including gastric, pancreatic, lung, and kidney cancer. In the present study, the expression of c-Met in 43 cases of gastric MALT lymphomas was immunohistochemically examined and compared with clinicopathological factors. To elucidate the significance of c-Met in MALT lymphoma, the expression intensity of c-Met in 22 API2-MALT1 translocation-positive and 21 API2-MALT1 translocation-negative cases was scored, compared, and examined. The immunohistochemistry analysis revealed strong staining for c-Met in 21 API2-MALT1 translocation-positive cases and in 1 translocation-negative case (P = 0.00). This result indicates the relationship between strong expression of c-Met and the progression of MALT lymphoma with API2-MALT1 gene translocation.
AB - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach is mainly associated with Helicobacter pylori infection, and H. pylori eradication therapy is often effective. However, 20–30% of the cases of MALT lymphoma are resistant to the eradication therapy, and translocation of the API2-MALT1 gene is often found in these cases. Most cases without translocation of API2-MALT1 are localized to the stomach, whereas some cases with this translocation are a more advanced stage of MALT lymphoma that spreads to other organs. The c-Met receptor is a prognostic factor involved in infiltration and metastasis in many malignant tumors, including gastric, pancreatic, lung, and kidney cancer. In the present study, the expression of c-Met in 43 cases of gastric MALT lymphomas was immunohistochemically examined and compared with clinicopathological factors. To elucidate the significance of c-Met in MALT lymphoma, the expression intensity of c-Met in 22 API2-MALT1 translocation-positive and 21 API2-MALT1 translocation-negative cases was scored, compared, and examined. The immunohistochemistry analysis revealed strong staining for c-Met in 21 API2-MALT1 translocation-positive cases and in 1 translocation-negative case (P = 0.00). This result indicates the relationship between strong expression of c-Met and the progression of MALT lymphoma with API2-MALT1 gene translocation.
KW - Chromosomal translocation
KW - Eradication
KW - HGF receptor
KW - Helicobacter pylori
KW - Mucosa-associated lymphoid tissue lymphoma
KW - Stomach neoplasms
KW - c-Met protein
UR - http://www.scopus.com/inward/record.url?scp=85077284567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077284567&partnerID=8YFLogxK
U2 - 10.1007/s00795-019-00241-6
DO - 10.1007/s00795-019-00241-6
M3 - Article
C2 - 31897734
AN - SCOPUS:85077284567
SN - 1860-1480
VL - 53
SP - 149
EP - 155
JO - Medical Molecular Morphology
JF - Medical Molecular Morphology
IS - 3
ER -
