Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

Y. Katayama; H. Takimoto; N. Fujii; G. Kimura; E. Omoto; M. Harada

doi:10.1038/sj.leu.2400708

Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

Y. Katayama, H. Takimoto, N. Fujii, G. Kimura, E. Omoto, M. Harada

University Hospital

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A 20-year-old Japanese man was referred because of severe pancytopenia with 14% of abnormal blasts in hypocellular bone marrow. After treatment by granulocyte colony-stimulating factor (G-CSF) and transfusions of red blood cells, spontaneous remission was subsequently achieved. After 3 months' remission, however, the patient developed AML characterized by the abnormal karyotype: 46XY,+8,t(9;11)(p22;q23). FISH study revealed the presence of trisomy 8 clone also in the hypoplastic state. While MLL-AF9 chimeric mRNA was observed in leukemic cells, it was not detectable in bone marrow cells from the hypoplastic state by RT-PCR. This is the first report of a trisomy 8 clone which evolved into one with a MLL gene rearrangement.

Original language	English
Pages (from-to)	1380-1382
Number of pages	3
Journal	Leukemia
Volume	11
Issue number	8
DOIs	https://doi.org/10.1038/sj.leu.2400708
Publication status	Published - 1997

Keywords

Clonal evolution
MLL gene rearrangement
Trisomy 8

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.leu.2400708

Cite this

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abstract = "A 20-year-old Japanese man was referred because of severe pancytopenia with 14% of abnormal blasts in hypocellular bone marrow. After treatment by granulocyte colony-stimulating factor (G-CSF) and transfusions of red blood cells, spontaneous remission was subsequently achieved. After 3 months' remission, however, the patient developed AML characterized by the abnormal karyotype: 46XY,+8,t(9;11)(p22;q23). FISH study revealed the presence of trisomy 8 clone also in the hypoplastic state. While MLL-AF9 chimeric mRNA was observed in leukemic cells, it was not detectable in bone marrow cells from the hypoplastic state by RT-PCR. This is the first report of a trisomy 8 clone which evolved into one with a MLL gene rearrangement.",

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T1 - Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

AU - Katayama, Y.

AU - Takimoto, H.

AU - Fujii, N.

AU - Kimura, G.

AU - Omoto, E.

AU - Harada, M.

PY - 1997

Y1 - 1997

N2 - A 20-year-old Japanese man was referred because of severe pancytopenia with 14% of abnormal blasts in hypocellular bone marrow. After treatment by granulocyte colony-stimulating factor (G-CSF) and transfusions of red blood cells, spontaneous remission was subsequently achieved. After 3 months' remission, however, the patient developed AML characterized by the abnormal karyotype: 46XY,+8,t(9;11)(p22;q23). FISH study revealed the presence of trisomy 8 clone also in the hypoplastic state. While MLL-AF9 chimeric mRNA was observed in leukemic cells, it was not detectable in bone marrow cells from the hypoplastic state by RT-PCR. This is the first report of a trisomy 8 clone which evolved into one with a MLL gene rearrangement.

AB - A 20-year-old Japanese man was referred because of severe pancytopenia with 14% of abnormal blasts in hypocellular bone marrow. After treatment by granulocyte colony-stimulating factor (G-CSF) and transfusions of red blood cells, spontaneous remission was subsequently achieved. After 3 months' remission, however, the patient developed AML characterized by the abnormal karyotype: 46XY,+8,t(9;11)(p22;q23). FISH study revealed the presence of trisomy 8 clone also in the hypoplastic state. While MLL-AF9 chimeric mRNA was observed in leukemic cells, it was not detectable in bone marrow cells from the hypoplastic state by RT-PCR. This is the first report of a trisomy 8 clone which evolved into one with a MLL gene rearrangement.

KW - Clonal evolution

KW - MLL gene rearrangement

KW - Trisomy 8

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Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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