Cloning and expression of the chick p63 gene

Akihiro Yasue; Hirotaka Tao; Tsutomu Nohno; Keiji Moriyama; Sumihare Noji; Hideyo Ohuchi

doi:10.1016/S0925-4773(00)00504-9

Cloning and expression of the chick p63 gene

Akihiro Yasue, Hirotaka Tao, Tsutomu Nohno, Keiji Moriyama, Sumihare Noji, Hideyo Ohuchi

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We have isolated a chick cDNA for p63, a member of the p53 transcription factor family. This cDNA encodes a protein of 582 amino acids for an α isoform in the C-terminal region, while lacking the N-terminal transactivation domain. The chick p63 gene is first expressed in the prospective cutaneous ectoderm at stage 6 and later in the developing epithelia. The p63 expression is intense in specialized epithelial structures, such as apical ectodermal ridge of the limb bud, epithelia of branchial arches and feather buds. Furthermore, we have found that the transcripts are detected in the interdigital epithelium, intersomite epithelium, and epaxial dermamyotome. (C) 2001 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	Mechanisms of Development
Volume	100
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4773(00)00504-9
Publication status	Published - 2001
Externally published	Yes

Keywords

AER
Apical ectodermal ridge
Branchial arch
Chick
Epithelium
Feather bud
Interdigital epithelium
Somite
p63

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(00)00504-9

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title = "Cloning and expression of the chick p63 gene",

abstract = "We have isolated a chick cDNA for p63, a member of the p53 transcription factor family. This cDNA encodes a protein of 582 amino acids for an α isoform in the C-terminal region, while lacking the N-terminal transactivation domain. The chick p63 gene is first expressed in the prospective cutaneous ectoderm at stage 6 and later in the developing epithelia. The p63 expression is intense in specialized epithelial structures, such as apical ectodermal ridge of the limb bud, epithelia of branchial arches and feather buds. Furthermore, we have found that the transcripts are detected in the interdigital epithelium, intersomite epithelium, and epaxial dermamyotome. (C) 2001 Elsevier Science Ireland Ltd.",

keywords = "AER, Apical ectodermal ridge, Branchial arch, Chick, Epithelium, Feather bud, Interdigital epithelium, Somite, p63",

author = "Akihiro Yasue and Hirotaka Tao and Tsutomu Nohno and Keiji Moriyama and Sumihare Noji and Hideyo Ohuchi",

note = "Funding Information: This work was supported by grants from the Japanese Ministry of Education, Science, Sports, and Culture to H.O., and from the Human Frontier Science Program, France to S.N.",

year = "2001",

doi = "10.1016/S0925-4773(00)00504-9",

language = "English",

volume = "100",

pages = "105--108",

journal = "Mechanisms of Development",

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publisher = "Elsevier BV",

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T1 - Cloning and expression of the chick p63 gene

AU - Yasue, Akihiro

AU - Tao, Hirotaka

AU - Nohno, Tsutomu

AU - Moriyama, Keiji

AU - Noji, Sumihare

AU - Ohuchi, Hideyo

N1 - Funding Information: This work was supported by grants from the Japanese Ministry of Education, Science, Sports, and Culture to H.O., and from the Human Frontier Science Program, France to S.N.

PY - 2001

Y1 - 2001

N2 - We have isolated a chick cDNA for p63, a member of the p53 transcription factor family. This cDNA encodes a protein of 582 amino acids for an α isoform in the C-terminal region, while lacking the N-terminal transactivation domain. The chick p63 gene is first expressed in the prospective cutaneous ectoderm at stage 6 and later in the developing epithelia. The p63 expression is intense in specialized epithelial structures, such as apical ectodermal ridge of the limb bud, epithelia of branchial arches and feather buds. Furthermore, we have found that the transcripts are detected in the interdigital epithelium, intersomite epithelium, and epaxial dermamyotome. (C) 2001 Elsevier Science Ireland Ltd.

AB - We have isolated a chick cDNA for p63, a member of the p53 transcription factor family. This cDNA encodes a protein of 582 amino acids for an α isoform in the C-terminal region, while lacking the N-terminal transactivation domain. The chick p63 gene is first expressed in the prospective cutaneous ectoderm at stage 6 and later in the developing epithelia. The p63 expression is intense in specialized epithelial structures, such as apical ectodermal ridge of the limb bud, epithelia of branchial arches and feather buds. Furthermore, we have found that the transcripts are detected in the interdigital epithelium, intersomite epithelium, and epaxial dermamyotome. (C) 2001 Elsevier Science Ireland Ltd.

KW - AER

KW - Apical ectodermal ridge

KW - Branchial arch

KW - Chick

KW - Epithelium

KW - Feather bud

KW - Interdigital epithelium

KW - Somite

KW - p63

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U2 - 10.1016/S0925-4773(00)00504-9

DO - 10.1016/S0925-4773(00)00504-9

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AN - SCOPUS:0035207789

SN - 0925-4773

VL - 100

SP - 105

EP - 108

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1

ER -

Cloning and expression of the chick p63 gene

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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