Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively

Timothy M. Olson; Satoshi Hirohata; Jean Ye; Kevin Leco; Michael F. Seldin; Suneel S. Apte

doi:10.1006/geno.1998.5362

Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively

Timothy M. Olson, Satoshi Hirohata, Jean Ye, Kevin Leco, Michael F. Seldin, Suneel S. Apte

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene. Like other members of the TIMP family, the TIMP-4 protein is encoded by five exons. These span 6 kb of genomic DNA, so that TIMP4 is similar in size to Timp1 but considerably smaller than TIMP2 and TIMP3. The exon-intron boundaries of TIMP4 are at locations very similar to those of the other TIMP genes, demonstrating the high degree of conservation of gene structure in this family. The human and mouse TIMP-4 genes map to comparable locations in the respective genomes, localizing to human chromosome 3p25 and mouse chromosome 6.

Original language	English
Pages (from-to)	148-151
Number of pages	4
Journal	Genomics
Volume	51
Issue number	1
DOIs	https://doi.org/10.1006/geno.1998.5362
Publication status	Published - Jul 1 1998
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively",

abstract = "We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene. Like other members of the TIMP family, the TIMP-4 protein is encoded by five exons. These span 6 kb of genomic DNA, so that TIMP4 is similar in size to Timp1 but considerably smaller than TIMP2 and TIMP3. The exon-intron boundaries of TIMP4 are at locations very similar to those of the other TIMP genes, demonstrating the high degree of conservation of gene structure in this family. The human and mouse TIMP-4 genes map to comparable locations in the respective genomes, localizing to human chromosome 3p25 and mouse chromosome 6.",

author = "Olson, {Timothy M.} and Satoshi Hirohata and Jean Ye and Kevin Leco and Seldin, {Michael F.} and Apte, {Suneel S.}",

note = "Funding Information: This work was supported by NIH Grants AR44436 (to Suneel S. Apte) and HGO0734 (to Michael F. Seldin) and American Heart Association Grant 96004630 to Timothy M. Olson. Support from the Cleveland Clinic Foundation (to Suneel S. Apte) and from Dr. Mark T. Keating and the Howard Hughes Medical Institute (to Timothy M. Olson) is gratefully acknowledged. K. Leco was supported by fellowships from Amgen and the Alberta Heritage Foundation for Medical Research.",

year = "1998",

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doi = "10.1006/geno.1998.5362",

language = "English",

volume = "51",

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T1 - Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively

AU - Olson, Timothy M.

AU - Hirohata, Satoshi

AU - Ye, Jean

AU - Leco, Kevin

AU - Seldin, Michael F.

AU - Apte, Suneel S.

N1 - Funding Information: This work was supported by NIH Grants AR44436 (to Suneel S. Apte) and HGO0734 (to Michael F. Seldin) and American Heart Association Grant 96004630 to Timothy M. Olson. Support from the Cleveland Clinic Foundation (to Suneel S. Apte) and from Dr. Mark T. Keating and the Howard Hughes Medical Institute (to Timothy M. Olson) is gratefully acknowledged. K. Leco was supported by fellowships from Amgen and the Alberta Heritage Foundation for Medical Research.

PY - 1998/7/1

Y1 - 1998/7/1

N2 - We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene. Like other members of the TIMP family, the TIMP-4 protein is encoded by five exons. These span 6 kb of genomic DNA, so that TIMP4 is similar in size to Timp1 but considerably smaller than TIMP2 and TIMP3. The exon-intron boundaries of TIMP4 are at locations very similar to those of the other TIMP genes, demonstrating the high degree of conservation of gene structure in this family. The human and mouse TIMP-4 genes map to comparable locations in the respective genomes, localizing to human chromosome 3p25 and mouse chromosome 6.

AB - We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene. Like other members of the TIMP family, the TIMP-4 protein is encoded by five exons. These span 6 kb of genomic DNA, so that TIMP4 is similar in size to Timp1 but considerably smaller than TIMP2 and TIMP3. The exon-intron boundaries of TIMP4 are at locations very similar to those of the other TIMP genes, demonstrating the high degree of conservation of gene structure in this family. The human and mouse TIMP-4 genes map to comparable locations in the respective genomes, localizing to human chromosome 3p25 and mouse chromosome 6.

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Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively

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