CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols

Moeko Otsu; Yuichi Suzuki; Afifa Ayu Koesoema; Hai Nam Hoang; Mayumi Tamura; Tomoko Matsuda

doi:10.1016/j.tetlet.2020.152424

CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols

Moeko Otsu, Yuichi Suzuki, Afifa Ayu Koesoema, Hai Nam Hoang, Mayumi Tamura, Tomoko Matsuda

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Pseudozyma (Candida) antarctica lipase B (CAL-B, Novozym 435®) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho-substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2-expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2-expanded hexane or CO2-expanded MeTHF.

Original language	English
Journal	Tetrahedron Letters
Volume	61
Issue number	42
DOIs	https://doi.org/10.1016/j.tetlet.2020.152424
Publication status	Published - 2020

Keywords

CO-expanded liquid
Lipase
-substituted 1-phenylethanol
Bio-based liquid

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10.1016/j.tetlet.2020.152424

http://www.sciencedirect.com/science/article/pii/S0040403920309023

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@article{734d989a0ebb4fcba280724c89b73f55,

title = "CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols",

abstract = "Pseudozyma (Candida) antarctica lipase B (CAL-B, Novozym 435{\textregistered}) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho-substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2-expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2-expanded hexane or CO2-expanded MeTHF.",

keywords = "CO-expanded liquid, Lipase, -substituted 1-phenylethanol, Bio-based liquid",

author = "Moeko Otsu and Yuichi Suzuki and Koesoema, {Afifa Ayu} and Hoang, {Hai Nam} and Mayumi Tamura and Tomoko Matsuda",

year = "2020",

doi = "10.1016/j.tetlet.2020.152424",

language = "English",

volume = "61",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "42",

}

TY - JOUR

T1 - CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols

AU - Otsu, Moeko

AU - Suzuki, Yuichi

AU - Koesoema, Afifa Ayu

AU - Hoang, Hai Nam

AU - Tamura, Mayumi

AU - Matsuda, Tomoko

PY - 2020

Y1 - 2020

N2 - Pseudozyma (Candida) antarctica lipase B (CAL-B, Novozym 435®) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho-substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2-expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2-expanded hexane or CO2-expanded MeTHF.

AB - Pseudozyma (Candida) antarctica lipase B (CAL-B, Novozym 435®) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho-substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2-expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2-expanded hexane or CO2-expanded MeTHF.

KW - CO-expanded liquid

KW - Lipase

KW - -substituted 1-phenylethanol

KW - Bio-based liquid

U2 - 10.1016/j.tetlet.2020.152424

DO - 10.1016/j.tetlet.2020.152424

M3 - Article

SN - 0040-4039

VL - 61

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols

Abstract

Keywords

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