Cochlin-tomoprotein (CTP) detection test identified perilymph leakage preoperatively in revision stapes surgery

Yuko Kataoka, Tetsuo Ikezono, Kunihiro Fukushima, Koji Yuen, Yukihide Maeda, Akiko Sugaya, Kazunori Nishizaki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Perilymphatic fistula (PLF) is defined as an abnormal leakage between perilymph from the labyrinth to the middle ear. Symptoms include hearing loss, tinnitus, and vertigo. The standard mode of PLF detection is intraoperative visualization of perilymph leakage and fistula, which ostensibly confirms the existence of PLF. Other possible methods of diagnosis include confirmation of pneumolabyrinth via diagnostic imaging. Recently, a cochlin-tomoprotein (CTP) detection test has been developed that allows definitive diagnosis of PLF-related hearing loss.We report the case of a 45-year-old man who presented with right-sided tinnitus, hearing loss, and dizziness 30. years after stapes surgery. Middle ear lavage was performed after myringotomy. A preoperative diagnosis of PLF was reached using the CTP detection test. Intraoperative observations included a necrotic long process of the incus, displaced wire piston, and fibrous tissue in the oval window. Perilymph leakage was not evident. The oval window was closed with fascia, and vertigo disappeared within 2. weeks postoperatively. When PLF is suspected after stapes surgery, the CTP detection test can be a useful, highly sensitive, and less invasive method for preoperative diagnosis.

Original languageEnglish
Pages (from-to)422-424
Number of pages3
JournalAuris Nasus Larynx
Issue number4
Publication statusPublished - Aug 2013


  • Cochlin
  • Cochlin-tomoprotein
  • Perilymphatic fistula
  • Stapes surgery

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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