Colocalization of tracks from boron neutron capture reactions and images of isolated cells

Ian Postuma; Patrizia Sommi; Agostina Vitali; Diyun Shu; Greta di Martino; Laura Cansolino; Cinzia Ferrari; Vittorio Ricci; Chiara Magni; Nicoletta Protti; Setareh Fatemi; Umberto Anselmi Tamburini; Silva Bortolussi; Saverio Altieri

doi:10.1016/j.apradiso.2020.109353

Colocalization of tracks from boron neutron capture reactions and images of isolated cells

Ian Postuma, Patrizia Sommi, Agostina Vitali, Diyun Shu, Greta di Martino, Laura Cansolino, Cinzia Ferrari, Vittorio Ricci, Chiara Magni, Nicoletta Protti, Setareh Fatemi, Umberto Anselmi Tamburini, Silva Bortolussi, Saverio Altieri

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.

Original language	English
Article number	109353
Journal	Applied Radiation and Isotopes
Volume	167
DOIs	https://doi.org/10.1016/j.apradiso.2020.109353
Publication status	Published - Jan 2021
Externally published	Yes

Keywords

BNCT
Boron
Cell cultures
Neutron autoradiography

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2020.109353

Cite this

Postuma, I., Sommi, P., Vitali, A., Shu, D., Martino, G. D., Cansolino, L., Ferrari, C., Ricci, V., Magni, C., Protti, N., Fatemi, S., Tamburini, U. A., Bortolussi, S., & Altieri, S. (2021). Colocalization of tracks from boron neutron capture reactions and images of isolated cells. Applied Radiation and Isotopes, 167, [109353]. https://doi.org/10.1016/j.apradiso.2020.109353

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title = "Colocalization of tracks from boron neutron capture reactions and images of isolated cells",

abstract = "In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.",

keywords = "BNCT, Boron, Cell cultures, Neutron autoradiography",

author = "Ian Postuma and Patrizia Sommi and Agostina Vitali and Diyun Shu and Martino, {Greta di} and Laura Cansolino and Cinzia Ferrari and Vittorio Ricci and Chiara Magni and Nicoletta Protti and Setareh Fatemi and Tamburini, {Umberto Anselmi} and Silva Bortolussi and Saverio Altieri",

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year = "2021",

month = jan,

doi = "10.1016/j.apradiso.2020.109353",

language = "English",

volume = "167",

journal = "Applied Radiation and Isotopes",

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T1 - Colocalization of tracks from boron neutron capture reactions and images of isolated cells

AU - Postuma, Ian

AU - Sommi, Patrizia

AU - Vitali, Agostina

AU - Shu, Diyun

AU - Martino, Greta di

AU - Cansolino, Laura

AU - Ferrari, Cinzia

AU - Ricci, Vittorio

AU - Magni, Chiara

AU - Protti, Nicoletta

AU - Fatemi, Setareh

AU - Tamburini, Umberto Anselmi

AU - Bortolussi, Silva

AU - Altieri, Saverio

PY - 2021/1

Y1 - 2021/1

N2 - In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.

AB - In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.

KW - BNCT

KW - Boron

KW - Cell cultures

KW - Neutron autoradiography

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JO - Applied Radiation and Isotopes

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ER -

Colocalization of tracks from boron neutron capture reactions and images of isolated cells

Abstract

Keywords

ASJC Scopus subject areas

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