Coloration of phenothiazines with metal-containing drugs

Kouichi Hosomi; Akihiro Okuno; Yoshiharu Umetani; Teruhisa Araya; Kenji Matsuyama; Jun Haginaka; Masaki Mifune; Yutaka Saito

doi:10.1248/yakushi.124.587

Coloration of phenothiazines with metal-containing drugs

Kouichi Hosomi, Akihiro Okuno, Yoshiharu Umetani, Teruhisa Araya, Kenji Matsuyama, Jun Haginaka, Masaki Mifune, Yutaka Saito

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the color change of phenothiazines and metal-containing drugs after compound formation, followed by use of FT-Raman spectrocopy to observe any structural changes in them. When 6 phenothiazines (thioridazine hydrochloride, prochlorperazine maleate, levomepromazine maleate, chlorpromazine phenolphthalinate, fluphenazine maleate and perphenazine fendiate) formed compounds with natural aluminum silicate, the color change was accompanied by a shift of FT-Raman signals. These changes could be attributed to the structural changes of phenothiazines. This present observation can be then used in advance to avoid coloration of phenothiazines during preparative procedures with metal-containing drugs such as antacids.

Original language	English
Pages (from-to)	587-598
Number of pages	12
Journal	Yakugaku Zasshi
Volume	124
Issue number	9
DOIs	https://doi.org/10.1248/yakushi.124.587
Publication status	Published - Sept 2004

Keywords

Coloration
Fourier transform Raman spectroscopy (FT-Raman)
Metal-containing drugs
Phenothiazines

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/yakushi.124.587

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title = "Coloration of phenothiazines with metal-containing drugs",

abstract = "We studied the color change of phenothiazines and metal-containing drugs after compound formation, followed by use of FT-Raman spectrocopy to observe any structural changes in them. When 6 phenothiazines (thioridazine hydrochloride, prochlorperazine maleate, levomepromazine maleate, chlorpromazine phenolphthalinate, fluphenazine maleate and perphenazine fendiate) formed compounds with natural aluminum silicate, the color change was accompanied by a shift of FT-Raman signals. These changes could be attributed to the structural changes of phenothiazines. This present observation can be then used in advance to avoid coloration of phenothiazines during preparative procedures with metal-containing drugs such as antacids.",

keywords = "Coloration, Fourier transform Raman spectroscopy (FT-Raman), Metal-containing drugs, Phenothiazines",

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AU - Hosomi, Kouichi

AU - Okuno, Akihiro

AU - Umetani, Yoshiharu

AU - Araya, Teruhisa

AU - Matsuyama, Kenji

AU - Haginaka, Jun

AU - Mifune, Masaki

AU - Saito, Yutaka

PY - 2004/9

Y1 - 2004/9

N2 - We studied the color change of phenothiazines and metal-containing drugs after compound formation, followed by use of FT-Raman spectrocopy to observe any structural changes in them. When 6 phenothiazines (thioridazine hydrochloride, prochlorperazine maleate, levomepromazine maleate, chlorpromazine phenolphthalinate, fluphenazine maleate and perphenazine fendiate) formed compounds with natural aluminum silicate, the color change was accompanied by a shift of FT-Raman signals. These changes could be attributed to the structural changes of phenothiazines. This present observation can be then used in advance to avoid coloration of phenothiazines during preparative procedures with metal-containing drugs such as antacids.

AB - We studied the color change of phenothiazines and metal-containing drugs after compound formation, followed by use of FT-Raman spectrocopy to observe any structural changes in them. When 6 phenothiazines (thioridazine hydrochloride, prochlorperazine maleate, levomepromazine maleate, chlorpromazine phenolphthalinate, fluphenazine maleate and perphenazine fendiate) formed compounds with natural aluminum silicate, the color change was accompanied by a shift of FT-Raman signals. These changes could be attributed to the structural changes of phenothiazines. This present observation can be then used in advance to avoid coloration of phenothiazines during preparative procedures with metal-containing drugs such as antacids.

KW - Coloration

KW - Fourier transform Raman spectroscopy (FT-Raman)

KW - Metal-containing drugs

KW - Phenothiazines

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Coloration of phenothiazines with metal-containing drugs

Abstract

Keywords

ASJC Scopus subject areas

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