Combination of renal angioplasty and angiotensin-converting-enzyme inhibitor can reduce proteinuria in patients with bilateral renal artery disease

Hironobu Toda; Haruhito A. Uchida; Kazufumi Nakamura; Hidemi Takeuchi; Masaru Kinomura; Koji Nakagawa; Atsuyuki Watanabe; Toru Miyoshi; Nobuhiro Nishii; Hiroshi Morita; Jun Wada; Hiroshi Ito

doi:10.2169/internalmedicine.2076-18

Combination of renal angioplasty and angiotensin-converting-enzyme inhibitor can reduce proteinuria in patients with bilateral renal artery disease

Hironobu Toda, Haruhito A. Uchida, Kazufumi Nakamura, Hidemi Takeuchi, Masaru Kinomura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Hiroshi Morita, Jun Wada, Hiroshi Ito

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Abstract

Recent large clinical trials failed to show clear benefits of percutaneous transluminal renal angioplasty (PTRA) as compared with medical therapy on patients with renal artery stenosis. It was also reported that proteinuria is an adverse prognostic factor after PTRA, and PTRA is less effective in patients with overt proteinuria. From the renoprotective point of view, to reduce proteinuria after PTRA is an important therapeutic goal in patients with renal artery stenosis with overt proteinuria. We hereby describe two patients successfully treated by combination therapy with PTRA and administration of angiotensin-converting enzyme (ACE) inhibitor for bilateral renal artery disease with overt proteinuria.

Original language	English
Pages (from-to)	1917-1922
Number of pages	6
Journal	Internal Medicine
Volume	58
Issue number	13
DOIs	https://doi.org/10.2169/internalmedicine.2076-18
Publication status	Published - 2019

Keywords

Angioplasty
Angiotensin-converting-enzyme inhibitor
Proteinuria
Renal artery disease

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.2076-18

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Toda, H., Uchida, H. A., Nakamura, K., Takeuchi, H., Kinomura, M., Nakagawa, K., Watanabe, A., Miyoshi, T., Nishii, N., Morita, H., Wada, J., & Ito, H. (2019). Combination of renal angioplasty and angiotensin-converting-enzyme inhibitor can reduce proteinuria in patients with bilateral renal artery disease. Internal Medicine, 58(13), 1917-1922. https://doi.org/10.2169/internalmedicine.2076-18

Toda, H , Uchida, HA , Nakamura, K , Takeuchi, H, Kinomura, M, Nakagawa, K, Watanabe, A, Miyoshi, T , Nishii, N , Morita, H , Wada, J & Ito, H 2019, 'Combination of renal angioplasty and angiotensin-converting-enzyme inhibitor can reduce proteinuria in patients with bilateral renal artery disease', Internal Medicine, vol. 58, no. 13, pp. 1917-1922. https://doi.org/10.2169/internalmedicine.2076-18

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title = "Combination of renal angioplasty and angiotensin-converting-enzyme inhibitor can reduce proteinuria in patients with bilateral renal artery disease",

abstract = "Recent large clinical trials failed to show clear benefits of percutaneous transluminal renal angioplasty (PTRA) as compared with medical therapy on patients with renal artery stenosis. It was also reported that proteinuria is an adverse prognostic factor after PTRA, and PTRA is less effective in patients with overt proteinuria. From the renoprotective point of view, to reduce proteinuria after PTRA is an important therapeutic goal in patients with renal artery stenosis with overt proteinuria. We hereby describe two patients successfully treated by combination therapy with PTRA and administration of angiotensin-converting enzyme (ACE) inhibitor for bilateral renal artery disease with overt proteinuria.",

keywords = "Angioplasty, Angiotensin-converting-enzyme inhibitor, Proteinuria, Renal artery disease",

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AU - Toda, Hironobu

AU - Uchida, Haruhito A.

AU - Nakamura, Kazufumi

AU - Takeuchi, Hidemi

AU - Kinomura, Masaru

AU - Nakagawa, Koji

AU - Watanabe, Atsuyuki

AU - Miyoshi, Toru

AU - Nishii, Nobuhiro

AU - Morita, Hiroshi

AU - Wada, Jun

AU - Ito, Hiroshi

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AB - Recent large clinical trials failed to show clear benefits of percutaneous transluminal renal angioplasty (PTRA) as compared with medical therapy on patients with renal artery stenosis. It was also reported that proteinuria is an adverse prognostic factor after PTRA, and PTRA is less effective in patients with overt proteinuria. From the renoprotective point of view, to reduce proteinuria after PTRA is an important therapeutic goal in patients with renal artery stenosis with overt proteinuria. We hereby describe two patients successfully treated by combination therapy with PTRA and administration of angiotensin-converting enzyme (ACE) inhibitor for bilateral renal artery disease with overt proteinuria.

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KW - Angiotensin-converting-enzyme inhibitor

KW - Proteinuria

KW - Renal artery disease

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Combination of renal angioplasty and angiotensin-converting-enzyme inhibitor can reduce proteinuria in patients with bilateral renal artery disease

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Keywords

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