Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

L. Cansolino; A. M. Clerici; C. Zonta; P. Dionigi; G. Mazzini; R. Di Liberto; S. Altieri; F. Ballarini; S. Bortolussi; M. P. Carante; M. Ferrari; S. J. González; I. Postuma; N. Protti; G. A. Santa Cruz; C. Ferrari

doi:10.1016/j.apradiso.2015.07.054

Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

L. Cansolino, A. M. Clerici, C. Zonta, P. Dionigi, G. Mazzini, R. Di Liberto, S. Altieri, F. Ballarini, S. Bortolussi, M. P. Carante, M. Ferrari, S. J. González, I. Postuma, N. Protti, G. A. Santa Cruz, C. Ferrari

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma.Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.

Original language	English
Pages (from-to)	226-232
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	106
DOIs	https://doi.org/10.1016/j.apradiso.2015.07.054
Publication status	Published - Dec 1 2015
Externally published	Yes

Keywords

BNCT
Cell cycle
Cell survival
Radiobiological effects

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2015.07.054

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Cansolino, L., Clerici, A. M., Zonta, C., Dionigi, P., Mazzini, G., Di Liberto, R., Altieri, S., Ballarini, F., Bortolussi, S., Carante, M. P., Ferrari, M., González, S. J., Postuma, I., Protti, N., Santa Cruz, G. A., & Ferrari, C. (2015). Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments. Applied Radiation and Isotopes, 106, 226-232. https://doi.org/10.1016/j.apradiso.2015.07.054

Cansolino, L, Clerici, AM, Zonta, C, Dionigi, P, Mazzini, G, Di Liberto, R, Altieri, S, Ballarini, F, Bortolussi, S, Carante, MP, Ferrari, M, González, SJ, Postuma, I, Protti, N, Santa Cruz, GA & Ferrari, C 2015, 'Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments', Applied Radiation and Isotopes, vol. 106, pp. 226-232. https://doi.org/10.1016/j.apradiso.2015.07.054

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title = "Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments",

abstract = "The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma.Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.",

keywords = "BNCT, Cell cycle, Cell survival, Radiobiological effects",

author = "L. Cansolino and Clerici, {A. M.} and C. Zonta and P. Dionigi and G. Mazzini and {Di Liberto}, R. and S. Altieri and F. Ballarini and S. Bortolussi and Carante, {M. P.} and M. Ferrari and Gonz{\'a}lez, {S. J.} and I. Postuma and N. Protti and {Santa Cruz}, {G. A.} and C. Ferrari",

note = "Funding Information: This work was partially supported by IRCCS S. Matteo Hospital, Pavia (Italy), Grant no. 80609 and by National Institute of Nuclear Physics (INFN) {"}NETTUNO experiments{"} Grant. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

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doi = "10.1016/j.apradiso.2015.07.054",

language = "English",

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T1 - Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

AU - Cansolino, L.

AU - Clerici, A. M.

AU - Zonta, C.

AU - Dionigi, P.

AU - Mazzini, G.

AU - Di Liberto, R.

AU - Altieri, S.

AU - Ballarini, F.

AU - Bortolussi, S.

AU - Carante, M. P.

AU - Ferrari, M.

AU - González, S. J.

AU - Postuma, I.

AU - Protti, N.

AU - Santa Cruz, G. A.

AU - Ferrari, C.

N1 - Funding Information: This work was partially supported by IRCCS S. Matteo Hospital, Pavia (Italy), Grant no. 80609 and by National Institute of Nuclear Physics (INFN) "NETTUNO experiments" Grant. Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma.Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.

AB - The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma.Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.

KW - BNCT

KW - Cell cycle

KW - Cell survival

KW - Radiobiological effects

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JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

Abstract

Keywords

ASJC Scopus subject areas

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