Comparative Study of Two Different Structures of Collagen Scaffold for Bone Formation

Andrea Paola Rodriguez; Hitoshi Nagatsuka; Bingzhen Huang; Kan Rui; Mika Okauchi; Noriyuki Nagai; Yoshie Kagawa; Missana Liliana; Shinichiro Oida

doi:10.2485/jhtb.14.210

Comparative Study of Two Different Structures of Collagen Scaffold for Bone Formation

Andrea Paola Rodriguez, Hitoshi Nagatsuka, Bingzhen Huang, Kan Rui, Mika Okauchi, Noriyuki Nagai, Yoshie Kagawa, Missana Liliana, Shinichiro Oida

Research output: Contribution to journal › Article › peer-review

Abstract

It has not been determined the best scaffold-structure for bone engineering. Because of this, we compared Honeycomb porous structure (HPS) and Interconnected porous structure (IPS) with or without KUSA/ A1 cells implanted in mice. The transplants were subjected to radiological and histological examinations after 1,2,4 and 8 weeks of implantation. KUSA/A1 cells alone showed small islands of new bone. Both scaffolds alone did not reveal any bone induction. KUSA/A1-HPS presented the scaffold partially filled with new bone. In contrast, KUSA/A1-IPS showed the whole scaffold filled with new bone. Our results indicated that cotton structure plays an important role in carrying the cells giving the precise size, shape and comfortable environment.

Original language	English
Pages (from-to)	210-211
Number of pages	2
Journal	Journal of Hard Tissue Biology
Volume	14
Issue number	2
DOIs	https://doi.org/10.2485/jhtb.14.210
Publication status	Published - 2005

Keywords

Honeycomb porous structure
Interconnected porous structure
KUSA/A1 cells

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry
Biomaterials
Orthopedics and Sports Medicine
Dentistry(all)
Cell Biology

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10.2485/jhtb.14.210

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abstract = "It has not been determined the best scaffold-structure for bone engineering. Because of this, we compared Honeycomb porous structure (HPS) and Interconnected porous structure (IPS) with or without KUSA/ A1 cells implanted in mice. The transplants were subjected to radiological and histological examinations after 1,2,4 and 8 weeks of implantation. KUSA/A1 cells alone showed small islands of new bone. Both scaffolds alone did not reveal any bone induction. KUSA/A1-HPS presented the scaffold partially filled with new bone. In contrast, KUSA/A1-IPS showed the whole scaffold filled with new bone. Our results indicated that cotton structure plays an important role in carrying the cells giving the precise size, shape and comfortable environment.",

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AU - Rodriguez, Andrea Paola

AU - Nagatsuka, Hitoshi

AU - Huang, Bingzhen

AU - Rui, Kan

AU - Okauchi, Mika

AU - Nagai, Noriyuki

AU - Kagawa, Yoshie

AU - Liliana, Missana

AU - Oida, Shinichiro

PY - 2005

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Comparative Study of Two Different Structures of Collagen Scaffold for Bone Formation

Abstract

Keywords

ASJC Scopus subject areas

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