Comparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome

Suketaka Iwanaga, Noriko Sakano, Kazuhisa Taketa, Noriko Takahashi, Da Hong Wang, Hidekazu Takahashi, Masayuki Kubo, Nobuyuki Miyatake, Keiki Ogino

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Objective: Metabolic syndrome (MS) is closely associated to life-style and is characterized by central obesity causing severe diseases such as diabetes mellitus (DM) or atherosclerosis. This study investigates the role of oxidative stress and inflammation in MS. Subjects: Total of 685 workers stratified by gender (293 men and 392 women) with a mean age of 41.2 ± 10.4 in different offices in a city in Japan. Methods: Fasting blood and urine tests for MS, oxidative and/or inflammatory biomarker analysis and blood pressure (BP) measurement were performed. MS was defined on the basis of the Japanese criterion. Results: Serum ferritin and urinary hydrogen peroxide (H2O2) levels were significantly higher in subjects with MS than those without. Ferritin was positively correlated with 8-hydroxy-2′- deoxyguanosine (8-OHdG) in all subjects and it was negatively correlated with 8-isoprostane and H2O2in men. In addition, there was a significant positive correlation between ferritin and homeostasis model assessment (HOMA-R) in men. By using multiple regression analysis, ferritin was closely correlated with HOMA-R, γ-GT, 8-OHdG, smoking value and amount of alcohol ingestion in men, and it was correlated with 8-OHdG, γ-GT, HOMA-R in women under 50 years old. Conclusions: Ferritin is a useful marker of MS including insulin resistance, reflecting the importance of oxidative stress as a cause of MS, especially in men.

Original languageEnglish
Pages (from-to)e271-e282
JournalObesity Research and Clinical Practice
Issue number3
Publication statusPublished - May 1 2014
Externally publishedYes


  • 8-Hydroxy-2′-deoxyguanosine (8-OHdG)
  • Ferritin
  • Metabolic syndrome
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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