Complexity in the treatment of pulmonary large cell neuroendocrine carcinoma

Toshiyuki Kozuki, Nobukazu Fujimoto, Hiroshi Ueoka, Katsuyuki Kiura, Keiichi Fujiwara, Katsuhiko Shiomi, Koichi Mizobuchi, Masahiro Tabata, Shuji Hamazaki, Mitsune Tanimoto

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


Purpose: According to the World Health Organization (WHO) classification of pulmonary large cell neuroendocrine carcinoma (LCNEC), one of the neuroendocrine tumors of the lung, is considered as a variant of non-small cell lung carcinoma. The objective of this study was to investigate the treatment strategy for LCNEC. Methods: We retrospectively reviewed the clinical information of 12 patients with LCNEC. Results: Three patients with stage I disease underwent curative resection but all relapsed within 20 months. One with stage IIA disease underwent non-curative resection received adjuvant chemoradiotherapy (cisplatin plus etoposide) and is well with no evidence of recurrence. Two with stage IIIB disease received concurrent chemoradiotherapy. Both achieved partial response (PR) but relapsed within 2 months. One elderly patient with stage IIIA disease received vinorelbine alone and did not respond. Of five patients with stage IV disease, three received platinum-based chemotherapy but no patient achieved PR. Of five patients with gefitinib as salvage therapy, one achieved PR. Conclusions: The prognosis of LCNEC is poor. To improve the outcome, we must evaluate the effectiveness of adjuvant or neoadjuvant therapy in patients with resectable disease. In addition, the evaluation of systemic and multimodality treatment strategies similar as in small cell lung cancer is worthy of consideration.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of cancer research and clinical oncology
Issue number3
Publication statusPublished - Mar 2005


  • Chemoradiotherapy
  • Chemotherapy
  • Gefitinib
  • Large cell neuroendocrine carcinoma (LCNEC)
  • Serum tumor marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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