Concentrations of pentosidine, an advanced glycation end-product, in umbilical cord blood

Hirokazu Tsukahara, Naoko Ohta, Shuko Sato, Masahiro Hiraoko, Ken Ichi Shukunami, Mayumi Uchiyama, Hisako Kawakami, Kyouichi Sekine, Mitsufumi Mayumi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Advanced glycation end-products (AGEs) are formed over several weeks to months by non-enzymatic glycation and oxidation ("glycoxidation") reactions between carbohydrate-derived carbonyl groups and protein amino groups, known as the Maillard reaction. Pentosidine is one of the best-characterized AGEs and is accepted as a satisfactory marker for glycoxidation in vivo. The present study was intended to measure pentosidine concentrations in umbilical cord blood from newborns with various gestational ages using our recently established high-performance liquid chromatography method [Tsukahara, H. et al. (2003) Pediatr. Res. 54, 419-424]. Our study demonstrates, for the first time, that pentosidine is detected in most of the umbilical blood samples. This study also shows that the umbilical blood concentrations of pentosidine are considerably lower than normal adult values, but that they increase with gestation progression and fetal growth. Umbilical pentosidine concentrations were significantly elevated in newborns of mothers with preeclampsia compared to those of mothers without preeclampsia. We conclude that accumulation of AGEs and oxidative stress occurs in fetal tissues and organs in utero at the early stage of human life and that their accumulation is augmented in the maternal preeclampsic condition.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalFree Radical Research
Issue number7
Publication statusPublished - Jul 2004
Externally publishedYes


  • Advanced glycation end-product
  • Newborn
  • Pentosidine
  • Preeclampsia
  • Umbilical blood

ASJC Scopus subject areas

  • Biochemistry


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