Concise synthesis of tetrahydrophenanthridone by palladium reagent

Takashi Harayama; Hiroko Toko; Hiromi Nishioka; Hitoshi Abe; Yasuo Takeuchi

doi:10.3987/COM-02-S51

Concise synthesis of tetrahydrophenanthridone by palladium reagent

Takashi Harayama, Hiroko Toko, Hiromi Nishioka, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Heck reaction of N-(2-halophenyl)-N-methyl-1-cyclohexene-1carboxamide (1) and 2-bromo-N-methyl-N-phenyl-1-cyclohexene-1-carboxamide (4) using a palladium reagent under several reaction conditions was examined. Reaction of 4 using Pd(OAc)₂, DPPP, and Bu₃P afforded tetrahydrophenanthridone (5) in excellent yield.

Original language	English
Pages (from-to)	541-546
Number of pages	6
Journal	Heterocycles
Volume	59
Issue number	2
DOIs	https://doi.org/10.3987/COM-02-S51
Publication status	Published - Mar 1 2003

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "Heck reaction of N-(2-halophenyl)-N-methyl-1-cyclohexene-1carboxamide (1) and 2-bromo-N-methyl-N-phenyl-1-cyclohexene-1-carboxamide (4) using a palladium reagent under several reaction conditions was examined. Reaction of 4 using Pd(OAc)2, DPPP, and Bu3P afforded tetrahydrophenanthridone (5) in excellent yield.",

author = "Takashi Harayama and Hiroko Toko and Hiromi Nishioka and Hitoshi Abe and Yasuo Takeuchi",

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T1 - Concise synthesis of tetrahydrophenanthridone by palladium reagent

AU - Harayama, Takashi

AU - Toko, Hiroko

AU - Nishioka, Hiromi

AU - Abe, Hitoshi

AU - Takeuchi, Yasuo

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Heck reaction of N-(2-halophenyl)-N-methyl-1-cyclohexene-1carboxamide (1) and 2-bromo-N-methyl-N-phenyl-1-cyclohexene-1-carboxamide (4) using a palladium reagent under several reaction conditions was examined. Reaction of 4 using Pd(OAc)2, DPPP, and Bu3P afforded tetrahydrophenanthridone (5) in excellent yield.

AB - Heck reaction of N-(2-halophenyl)-N-methyl-1-cyclohexene-1carboxamide (1) and 2-bromo-N-methyl-N-phenyl-1-cyclohexene-1-carboxamide (4) using a palladium reagent under several reaction conditions was examined. Reaction of 4 using Pd(OAc)2, DPPP, and Bu3P afforded tetrahydrophenanthridone (5) in excellent yield.

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EP - 546

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Concise synthesis of tetrahydrophenanthridone by palladium reagent

Abstract

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