TY - JOUR
T1 - Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
AU - Kiso, Sayaka
AU - Sugiura, Hiroyuki
AU - Kuroi, Taiga
AU - Omote, Rika
AU - Toji, Tomohiro
AU - Ishikawa, Tatsunori
AU - Okamoto, Sachiyo
AU - Nomura, Naho
AU - Masunari, Taro
AU - Sezaki, Nobuo
AU - Kiguchi, Toru
AU - Tanimoto, Mitsune
N1 - Publisher Copyright:
© 2021 The Author(s). Published by S. Karger AG, Basel.
PY - 2021/11/30
Y1 - 2021/11/30
N2 - The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient's lifetime because of the atypical phenotype. However, autopsy revealed that the patient's bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.
AB - The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient's lifetime because of the atypical phenotype. However, autopsy revealed that the patient's bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.
KW - Acute myeloid leukemia
KW - Autopsy
KW - Chronic lymphocytic leukemia
KW - Flow cytometry
KW - Immunohistochemical staining
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U2 - 10.1159/000520427
DO - 10.1159/000520427
M3 - Article
AN - SCOPUS:85120641384
SN - 1662-6575
VL - 14
SP - 1725
EP - 1732
JO - Case Reports in Oncology
JF - Case Reports in Oncology
IS - 3
ER -