TY - JOUR
T1 - Condensation reaction between angiotensin II and dicarboxylic acid in water at high temperature without any catalytic agent additive
AU - Asano, Takamitsu
AU - Maeda, Atsushi
AU - Kimura, Yukitaka
AU - Takahashi, Taro
AU - Nakamura, Akihiro
AU - Maeda, Hirokazu
AU - Adachi, Shuji
PY - 2005/7
Y1 - 2005/7
N2 - The condensation reaction of angiotensin II and tartaric acid in water at 100-140°C proceeded without any added catalytic agent. One of the products, N-CO-tartarylangiotensin II, was confirmed by LC-MS, positive-ion MALDI-MS, and the fluorescamine method as a condensation product. The initial concentration of the substrates, temperatures, and initial pH affected the yield of the product. The higher concentrations and temperatures increased the concentration of the condensation product. The optimal pH for the condensation reaction was 3.0. The other C4 saturated dicarboxylic acids, malic and succinic acids, were also condensed by angiotensin II.
AB - The condensation reaction of angiotensin II and tartaric acid in water at 100-140°C proceeded without any added catalytic agent. One of the products, N-CO-tartarylangiotensin II, was confirmed by LC-MS, positive-ion MALDI-MS, and the fluorescamine method as a condensation product. The initial concentration of the substrates, temperatures, and initial pH affected the yield of the product. The higher concentrations and temperatures increased the concentration of the condensation product. The optimal pH for the condensation reaction was 3.0. The other C4 saturated dicarboxylic acids, malic and succinic acids, were also condensed by angiotensin II.
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U2 - 10.1021/bp050058n
DO - 10.1021/bp050058n
M3 - Article
C2 - 16080698
AN - SCOPUS:23244436979
SN - 8756-7938
VL - 21
SP - 1169
EP - 1174
JO - Biotechnology Progress
JF - Biotechnology Progress
IS - 4
ER -