Conformational transmission in ATP synthase during catalysis: Search for large structural changes

Masamitsu Futai, Hiroshi Omote

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)


Escherichia coli ATP synthase has eight subunits and functions through transmission of conformational changes between subunits. Defective mutation at βGly-149 was suppressed by the second mutations at the outer surface of the β subunit, indicating that the defect by the first mutation was suppressed by the second mutation through long range conformation transmission. Extensive mutant/pseudorevertant studies revealed that β/α and β/γ subunits interactions are important for the energy coupling between catalysis and H+ translocation. In addition, long range interaction between amino and carboxyl terminal regions of the γ subunit has a critical role(s) for energy coupling. These results suggest that the dynamic conformation change and its transmission are essential for ATP synthase.

Original languageEnglish
Pages (from-to)409-414
Number of pages6
JournalJournal of Bioenergetics and Biomembranes
Issue number5
Publication statusPublished - Jan 1 1996
Externally publishedYes


  • ATP synthase
  • conformation transmission
  • mutagenesis
  • pseudorevertant
  • rotational catalysis

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


Dive into the research topics of 'Conformational transmission in ATP synthase during catalysis: Search for large structural changes'. Together they form a unique fingerprint.

Cite this