Conjugate reduction of α,β-unsaturated ketones with hydrosilane mediated by copper(I) salt

Atsunori Mori; Akinori Fujita; Hiroshi Kajiro; Yasushi Nishihara; Tamejiro Hiyama

doi:10.1016/S0040-4020(99)00141-6

Conjugate reduction of α,β-unsaturated ketones with hydrosilane mediated by copper(I) salt

Atsunori Mori, Akinori Fujita, Hiroshi Kajiro, Yasushi Nishihara, Tamejiro Hiyama

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Reduction of several α,β-unsaturated ketones with dimethylphenylsilane and 10-100 mol% of CuF(PPh₃)₃ · 2EtOH or CuCl/PPh₃/Bu₄NF proceeds in a 1,4-selective manner to give the corresponding saturated ketones in up to >99% yield.

Original language	English
Pages (from-to)	4573-4582
Number of pages	10
Journal	Tetrahedron
Volume	55
Issue number	15
DOIs	https://doi.org/10.1016/S0040-4020(99)00141-6
Publication status	Published - Apr 9 1999
Externally published	Yes

Keywords

Copper and compounds
Ketones
Reduction
Silicon and compounds

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(99)00141-6

Cite this

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title = "Conjugate reduction of α,β-unsaturated ketones with hydrosilane mediated by copper(I) salt",

abstract = "Reduction of several α,β-unsaturated ketones with dimethylphenylsilane and 10-100 mol% of CuF(PPh3)3 · 2EtOH or CuCl/PPh3/Bu4NF proceeds in a 1,4-selective manner to give the corresponding saturated ketones in up to >99% yield.",

keywords = "Copper and compounds, Ketones, Reduction, Silicon and compounds",

author = "Atsunori Mori and Akinori Fujita and Hiroshi Kajiro and Yasushi Nishihara and Tamejiro Hiyama",

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doi = "10.1016/S0040-4020(99)00141-6",

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T1 - Conjugate reduction of α,β-unsaturated ketones with hydrosilane mediated by copper(I) salt

AU - Mori, Atsunori

AU - Fujita, Akinori

AU - Kajiro, Hiroshi

AU - Nishihara, Yasushi

AU - Hiyama, Tamejiro

N1 - Funding Information: The authorst hankS hin-EtsuC hemicaCl o. Ltd. for generouds onationo f organosilicorne agents. This work was partiallys upportedb y a Grant-in-Aidf or Scientific Researcho n Priority Areas (No. 09239102b) y the Ministryo f EducationS, cienceS, portsa ndC ulture,J apan.

PY - 1999/4/9

Y1 - 1999/4/9

N2 - Reduction of several α,β-unsaturated ketones with dimethylphenylsilane and 10-100 mol% of CuF(PPh3)3 · 2EtOH or CuCl/PPh3/Bu4NF proceeds in a 1,4-selective manner to give the corresponding saturated ketones in up to >99% yield.

AB - Reduction of several α,β-unsaturated ketones with dimethylphenylsilane and 10-100 mol% of CuF(PPh3)3 · 2EtOH or CuCl/PPh3/Bu4NF proceeds in a 1,4-selective manner to give the corresponding saturated ketones in up to >99% yield.

KW - Copper and compounds

KW - Ketones

KW - Reduction

KW - Silicon and compounds

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U2 - 10.1016/S0040-4020(99)00141-6

DO - 10.1016/S0040-4020(99)00141-6

M3 - Article

AN - SCOPUS:0033537956

SN - 0040-4020

VL - 55

SP - 4573

EP - 4582

JO - Tetrahedron

JF - Tetrahedron

IS - 15

ER -

Conjugate reduction of α,β-unsaturated ketones with hydrosilane mediated by copper(I) salt

Abstract

Keywords

ASJC Scopus subject areas

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