Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants

Ronnie De Jonge; H. Peter Van Esse; Anja Kombrink; Tomonori Shinya; Yoshitake Desaki; Ralph Bours; Sander Van Der Krol; Naoto Shibuya; Matthieu H.A.J. Joosten; Bart P.H.J. Thomma

doi:10.1126/science.1190859

Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants

Ronnie De Jonge, H. Peter Van Esse, Anja Kombrink, Tomonori Shinya, Yoshitake Desaki, Ralph Bours, Sander Van Der Krol, Naoto Shibuya, Matthieu H.A.J. Joosten, Bart P.H.J. Thomma

Research output: Contribution to journal › Article › peer-review

529 Citations (Scopus)

Abstract

Multicellular organisms activate immunity upon recognition of pathogen-associated molecular patterns (PAMPs). Chitin is the major component of fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and mammalian cells. Microbial pathogens deliver effector proteins to suppress PAMP-triggered host immunity and to establish infection. Here, we show that the LysM domain-containing effector protein Ecp6 of the fungal plant pathogen Cladosporium fulvum mediates virulence through perturbation of chitin-triggered host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that are released from the cell walls of invading hyphae to prevent elicitation of host immunity. This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom.

Original language	English
Pages (from-to)	953-955
Number of pages	3
Journal	Science
Volume	329
Issue number	5994
DOIs	https://doi.org/10.1126/science.1190859
Publication status	Published - Aug 20 2010
Externally published	Yes

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title = "Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants",

abstract = "Multicellular organisms activate immunity upon recognition of pathogen-associated molecular patterns (PAMPs). Chitin is the major component of fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and mammalian cells. Microbial pathogens deliver effector proteins to suppress PAMP-triggered host immunity and to establish infection. Here, we show that the LysM domain-containing effector protein Ecp6 of the fungal plant pathogen Cladosporium fulvum mediates virulence through perturbation of chitin-triggered host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that are released from the cell walls of invading hyphae to prevent elicitation of host immunity. This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom.",

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AU - De Jonge, Ronnie

AU - Van Esse, H. Peter

AU - Kombrink, Anja

AU - Shinya, Tomonori

AU - Desaki, Yoshitake

AU - Bours, Ralph

AU - Van Der Krol, Sander

AU - Shibuya, Naoto

AU - Joosten, Matthieu H.A.J.

AU - Thomma, Bart P.H.J.

PY - 2010/8/20

Y1 - 2010/8/20

N2 - Multicellular organisms activate immunity upon recognition of pathogen-associated molecular patterns (PAMPs). Chitin is the major component of fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and mammalian cells. Microbial pathogens deliver effector proteins to suppress PAMP-triggered host immunity and to establish infection. Here, we show that the LysM domain-containing effector protein Ecp6 of the fungal plant pathogen Cladosporium fulvum mediates virulence through perturbation of chitin-triggered host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that are released from the cell walls of invading hyphae to prevent elicitation of host immunity. This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom.

AB - Multicellular organisms activate immunity upon recognition of pathogen-associated molecular patterns (PAMPs). Chitin is the major component of fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and mammalian cells. Microbial pathogens deliver effector proteins to suppress PAMP-triggered host immunity and to establish infection. Here, we show that the LysM domain-containing effector protein Ecp6 of the fungal plant pathogen Cladosporium fulvum mediates virulence through perturbation of chitin-triggered host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that are released from the cell walls of invading hyphae to prevent elicitation of host immunity. This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom.

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Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants

Abstract

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