Constituents of Psoralea corylifolia fruits and their effects on methicillin-resistant Staphylococcus aureus

Yanmei Cui; Shoko Taniguchi; Teruo Kuroda; Tsutomu Hatano

doi:10.3390/molecules200712500

Constituents of Psoralea corylifolia fruits and their effects on methicillin-resistant Staphylococcus aureus

Yanmei Cui, Shoko Taniguchi, Teruo Kuroda, Tsutomu Hatano

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.

Original language	English
Pages (from-to)	12500-12511
Number of pages	12
Journal	Molecules
Volume	20
Issue number	7
DOIs	https://doi.org/10.3390/molecules200712500
Publication status	Published - Jul 1 2015

Keywords

Bakuflavanone
Bakuisoflavone
Methicillin-resistant staphylococcus aureus
Psoralea corylifolia

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules200712500

Cite this

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title = "Constituents of Psoralea corylifolia fruits and their effects on methicillin-resistant Staphylococcus aureus",

abstract = "Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.",

keywords = "Bakuflavanone, Bakuisoflavone, Methicillin-resistant staphylococcus aureus, Psoralea corylifolia",

author = "Yanmei Cui and Shoko Taniguchi and Teruo Kuroda and Tsutomu Hatano",

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AU - Cui, Yanmei

AU - Taniguchi, Shoko

AU - Kuroda, Teruo

AU - Hatano, Tsutomu

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.

AB - Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.

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KW - Methicillin-resistant staphylococcus aureus

KW - Psoralea corylifolia

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Constituents of Psoralea corylifolia fruits and their effects on methicillin-resistant Staphylococcus aureus

Abstract

Keywords

ASJC Scopus subject areas

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