Continuous renal replacement therapy: Does technique influence electrolyte and bicarbonate control?

H. Morimatsu, S. Uchino, Rinaldo Bellomo, C. Ronco

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Background and objectives: Different techniques of continuous renal replacement therapy (CRRT) might have different effects on electrolyte and acid-base control. The aim of this study was to determine whether continuous veno-venous hemodiafiltration (CVVHDF) or continuous veno-venous hemofiltration (CVVH) achieve better control of serum sodium, potassium and bicarbonate concentrations. Design: Retrospective controlled study. Setting: Two tertiary intensive care units. Patients: Critically ill patients with acute renal failure (ARF) treated with CVVHDF (n=49) or CVVH (n=50). Interventions: Retrieval of daily morning sodium and potassium values and arterial bicarbonate levels from computerized biochemical records before and after the initiation of CRRT for up to 2 weeks of treatment. Statistical comparison of findings. Measurements and results: Before treatment, abnormal (high or low) values were frequently observed for sodium (65.1% for CVVHDF vs. 80.0% for CVVH; NS), potassium (45.9% vs. 34.0%; NS), and bicarbonate (73.3% vs. 68.0%; NS). After treatment, however, CVVHDF was more likely to achieve serum sodium concentrations within the normal range (74.1% vs. 62.9%; p=0.0026). Both treatments decreased the mean serum potassium concentration over the first 48 h (p=0.0059 and p>0.0001, respectively), but there was no difference in terms of the normalization of serum potassium concentration during the entire treatment period (88.3% vs. 90.5%; NS). Both treatments increased the mean arterial bicarbonate concentration over the first 48 hours (p=0.011 and p<0.0001, respectively). However, CVVH was associated with a lower incidence of metabolic acidosis (13.8% for CVVH vs. 34.5% for CVVHDF; p<0.0001) and a higher incidence of metabolic alkalosis (38.9% vs. 1.1%; p<0.0001) during the entire treatment period. Conclusions: CRRT strategies based on different techniques have a significantly different impact on sodium and bicarbonate control.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalInternational Journal of Artificial Organs
Issue number4
Publication statusPublished - Apr 1 2003
Externally publishedYes


  • Acute renal failure
  • Bicarbonate
  • Hemodialysis
  • Hemofiltration
  • Potassium
  • Sodium

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Continuous renal replacement therapy: Does technique influence electrolyte and bicarbonate control?'. Together they form a unique fingerprint.

Cite this